Table 3.
Parameter values [median and interquartile range (IQR)] for the final full model and the final model after eliminating CYP3A5 genotype as a covariate. The bioavailability (F) of the CYP3A5 expressers was tested relative to the CYP3A5 nonexpressers for which F was set to 1.0 in the Full model, while F was included as a parameter affecting all patients in the No CYP3A5 model.
| Parameter | Full model | No CYP3A5 model | ||
|---|---|---|---|---|
| Median | IQR | Median | IQR | |
| Apparent clearance for CYP3A5 expressers (CL/FCYP) [L/h] | 26.7 | 13.2 | – | – |
| Apparent clearance for CYP3A5 nonexpressers (CL/FnoCYP) [L/h] | 21.2 | 11.0 | – | – |
| Apparent clearance (CL/F) [L/h] | – | – | 17.3 | 13.6 |
| Apparent intercompartment clearance (Q/F) [L/h] | 19.5 | 32.3 | 13.9 | 28.5 |
| Apparent central volume of distribution (V/F) [L] | 177 | 295 | 190 | 266 |
| Apparent peripheral volume of distribution (Vp/F) [L] | 3707 | 7736 | 2982 | 4155 |
| Relative bioavailability (FA) | 0.63* | 0.12 | 0.79† | 0.26 |
| Lag time first week (Tlag1) [h] | 1.00 | 1.55 | 1.08 | 1.59 |
| Lag time week 2-4 (Tlag2) [h] | 0.15 | 0.46 | 0.16 | 0.46 |
| Lag time after first month (Tlag3) [h] | 0.59 | 0.57 | 0.44 | 0.48 |
| Absorption rate constant (Ka) [h] | 1.04 | 1.27 | 1.14 | 1.24 |
*
FA for CYP3A5 expressers versus nonexpressers (FA = 1).
†
FA for the whole population (not relative to any subpopulation).
CYP3A5, cytochrome P450-3A5, IQR, interquartile range.