Table 4.
The models (with and without CYP3A5 genotype as covariate) median (IQR) predictive error for the next concentration (PE, predicted versus observed concentration, of the 1st to the 9th concentrations) when provided all from none to the eight first Tac concentrations after transplantation.
| Conc No | With CYP3A5 | Without CYP3A5 | ||
|---|---|---|---|---|
| Median PE | IQR | Median PE | IQR | |
| 1 | −1.47 | 4.67 | −1.89 | 4.44 |
| 2 | −0.47 | 4.46 | −0.70 | 3.37 |
| 3 | 0.11 | 4.69 | −0.21 | 3.93 |
| 4 | 0.12 | 3.64 | −0.58 | 2.75 |
| 5 | 0.24 | 2.93 | 0.19 | 2.09 |
| 6 | 0.41 | 2.54 | 0.58 | 2.34 |
| 7 | −0.49 | 3.42 | 0.14 | 2.54 |
| 8 | 0.28 | 2.55 | −0.13 | 2.12 |
| 9 | −0.14 | 2.36 | 0.01 | 1.57 |
CYP3A5, cytochrome P450 3A5.