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. Author manuscript; available in PMC: 2013 Dec 5.
Published in final edited form as: Stat Med. 2010 Mar 30;29(0):10.1002/sim.3802. doi: 10.1002/sim.3802

Table II.

Optimal designs for the linear regression and Emax model for various optimality criteria. The quantity Δ* is defined by Δ* = ϑ1ϑ2 (d̄ − ḏ)/{2( + ϑ2)( + ϑ2)}, while the quantity w(ϑ2) is given by w(ϑ2)=1/4(d¯d¯)ϑ2ϑ1/{8[(d¯d¯)ϑ2ϑ1+Δϑ2(d¯+d¯)+Δ(ϑ22+d¯d¯)]}.

linear variance Emax variance
D
(d¯d¯1212)
n.a.
(d¯(d¯+ϑ2)d¯+(d¯+ϑ2)d¯2ϑ2+d¯+d¯d¯131313)
n.a.
EDp any 0
(d¯(d¯+ϑ2)d¯+(d¯+ϑ2)d¯2ϑ2+d¯+d¯d¯141214)
σ2n(8p(1p)(ϑ2+d¯)2(ϑ2+d¯)2ϑ1ϑ2(ϑ2+pd¯+(1p)d¯)2)2
MED Δ < Δ*
(d¯d¯1212)
2σ2Δ2nϑ14(d¯2+d¯2)
(d¯(d¯+ϑ2)d¯+(d¯+ϑ2)d¯2ϑ2+d¯+d¯d¯w(ϑ)1212w(ϑ))
σ2n4ϑ12ϑ22(d¯+ϑ2)4(ϑ1ϑ2Δ(d¯+ϑ2))4
MED Δ > Δ*
(d¯d¯1212)
2σ2Δ2nϑ14(d¯2+d¯2)
(d¯ϑ2(Δϑ2+(Δ+ϑ1)d¯ϑ2ϑ1Δ(d¯+ϑ2)1212)
8σ2nΔ2(d¯+ϑ2)6(d¯+ϑ2)2{(d¯d¯)ϑ1ϑ2+Δ(ϑ2+d¯)(ϑ2+d¯)}2ϑ22ϑ24(d¯d¯)4(Δ(d¯+ϑ2)ϑ1ϑ2)2

n.a. = not available