Table 1.
Selected gene sets associated with clustering-defined groups of clones of melanoma cell line LM-MEL-62
| Gene set description | NES | FDR | MSigDB ID |
|---|---|---|---|
|
Genes sets enriched in Clones 4,7,8,9 | |||
| Up-regulated in melanoma patients with distant metastasis within 4 years |
2.60 |
0.000 |
M6387 |
| DNA repair and replication genes up-regulated in melanoma patients who relapsed |
2.46 |
0.000 |
M2431 |
| Up-regulated in metastases to primary melanomas |
2.14 |
0.000 |
M5740 |
|
Genes sets enriched in Clones 1,5,6 | |||
| Genes up-regulated in fibroblasts after interferon alpha treatment |
2.10 |
0.000 |
M9221 |
| Tumor necrosis factor pathway |
1.95 |
0.003 |
M18030 |
| NOTCH signaling |
1.89 |
0.006 |
M7946 |
|
Genes sets enriched in 2,3,10 | |||
| Genes up-regulated in MET over-expressing colon cancer xenografts |
2.23 |
0.000 |
M3231 |
| Genes involved in G beta:gamma signaling through PI3Kgamma | 1.79 | 0.046 | M14301 |
NES – normalized enrichment score. FDR – false discovery rate.