Table 3.
Pharmacokinetic parameters following a 150 mg/kg taurolidine infusion over 2 hrs
| ID | Cmax (ug/mL) | Tmax (hr) | Lambda_z (1/hr) | t1/2 (hr) | AUClast (hr*ug/mL) | AUCINF (hr*ug/mL) | CL (L/hr/kg) | Vss (L/kg) | MRT (hr) |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
65.6 |
1.50 |
0.192 |
3.6 |
178 |
197 |
0.763 |
3.11 |
4.1 |
| 2 |
144.8 |
2.00 |
0.203 |
3.4 |
667 |
680 |
0.221 |
0.85 |
3.9 |
| 3 |
185.0 |
1.50 |
0.201 |
3.5 |
457 |
467 |
0.321 |
0.97 |
3.0 |
| 4 |
145.1 |
1.25 |
0.201 |
3.4 |
337 |
339 |
0.442 |
1.26 |
2.8 |
| 5 |
162.5 |
2.08 |
0.183 |
3.8 |
684 |
698 |
0.215 |
1.09 |
5.1 |
| 6 |
139.7 |
1.75 |
0.272 |
2.6 |
346 |
348 |
0.431 |
1.09 |
2.5 |
| Mean |
140.5 |
1.63* |
0.209 |
3.4 |
445 |
455 |
0.399 |
1.39 |
3.6 |
| SD |
40.3 |
NA |
0.032 |
0.4 |
200 |
201 |
0.204 |
0.85 |
0.9 |
| CV% | 28.7 | NA | 15.3 | 12.7 | 44.9 | 44.1 | 51.0 | 60.9 | 26.5 |
*median; Cmax Maximum concentration, Tmax Time to Cmax, t1/2 serum half-life, AUClast area under the curve to last quantifiable concentration, AUCINF Area under the serum concentration-time profile from time zero, CL Clearance, Vss Volume of distribution at steady state, and MRT Mean residence time.