Table 4.

Number of events for toxicities associated with the administration of taurolidine to dogs with osteosarcoma

Toxicity	Grade I	Circumstances	Grade II	Circumstances
Bone marrow
Neutropenia	7	1 when T combined with D	2	Both when T combined with C
		6 when T combined with C
Thrombocytopenia	2	1 when T alone	3	2 when T combined with D
		1 when T combined with D
				1 when T combined with C
Gastrointestinal
Anorexia	4	2 when T combined with D	5	3 when T combined with D
		1 when T combined with C		2 when T combined with C
		1 when T given by itself one week after C
Diarrhea	3	2 when T combined with D	0
		1 when T combined with C

T = taurolidine, D = doxorubicin, C = carboplatin.