Table 3B.
Single variant associations with PD in the Irish series (362 patients with PD, 370 controls)
| Additive model | Dominant model | Recessive model | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Variant | Minor allele | MAF | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value |
| rs2230288 | T | 1.8% | 4.29 (1.58 - 11.67) | 0.0043 | 4.29 (1.58 - 11.67) | 0.0043 | N/A | N/A |
| rs34372695 | T | 1.5% | 2.42 (0.90 - 6.51) | 0.079 | 2.42 (0.90 - 6.51) | 0.079 | N/A | N/A |
| rs708723 | C | 44.7% | 0.82 (0.66 - 1.01) | 0.066 | 0.68 (0.49 - 0.95) | 0.024 | 0.88 (0.60 - 1.29) | 0.52 |
| rs10928513 | T | 42.5% | 0.84 (0.68 - 1.04) | 0.10 | 0.86 (0.63 - 1.19) | 0.37 | 0.69 (0.47 - 1.02) | 0.060 |
| rs2102808 | T | 14.0% | 1.18 (0.87 - 1.59) | 0.30 | 1.17 (0.83 - 1.66) | 0.37 | 1.53 (0.56 - 4.17) | 0.40 |
| rs11711441 | A | 10.8% | 0.63 (0.45 - 0.90) | 0.011 | 0.65 (0.44 - 0.95) | 0.028 | 0.20 (0.04 - 0.96) | 0.045 |
| rs6599388 | T | 30.7% | 1.02 (0.81 - 1.28) | 0.85 | 0.89 (0.66 - 1.21) | 0.46 | 1.53 (0.92 - 2.54) | 0.098 |
| rs11724635 | C | 44.4% | 0.78 (0.63 - 0.96) | 0.019 | 0.68 (0.49 - 0.94) | 0.021 | 0.75 (0.51 - 1.09) | 0.13 |
| rs6812193 | T | 38.2% | 0.88 (0.71 - 1.09) | 0.25 | 0.91 (0.67 - 1.25) | 0.57 | 0.73 (0.48 - 1.12) | 0.15 |
| rs356219 | G | 42.1% | 1.79 (1.44 - 2.24) | 2.7 x 10-7 | 2.38 (1.71 - 3.31) | 2.7 x 10-7 | 1.90 (1.27 - 2.83) | 0.0016 |
| rs3129882 | G | 38.2% | 0.87 (0.69 - 1.09) | 0.23 | 1.02 (0.75 - 1.41) | 0.88 | 0.55 (0.35 - 0.87) | 0.011 |
| rs156429 | G | 37.3% | 0.97 (0.77 - 1.21) | 0.78 | 1.06 (0.77 - 1.44) | 0.73 | 0.79 (0.50 - 1.23) | 0.30 |
| rs7077361 | C | 12.1% | 1.15 (0.82 - 1.61) | 0.43 | 1.17 (0.82 - 1.67) | 0.40 | 0.93 (0.17 – 5.00) | 0.93 |
| rs1491942 | C | 20.8% | 1.21 (0.93 - 1.58) | 0.15 | 1.18 (0.86 - 1.61) | 0.30 | 1.87 (0.87 - 4.04) | 0.11 |
| rs10847864 | T | 36.9% | 1.08 (0.86 - 1.35) | 0.51 | 1.11 (0.81 - 1.52) | 0.51 | 1.09 (0.70 - 1.71) | 0.70 |
| rs2942168 | A | 19.1% | 0.63 (0.48 - 0.83) | 0.0009 | 0.59 (0.43 - 0.82) | 0.0016 | 0.46 (0.22 – 1.00) | 0.050 |
| rs12456492 | G | 32.3% | 0.93 (0.74 - 1.18) | 0.54 | 1.03 (0.75 - 1.40) | 0.86 | 0.66 (0.39 - 1.10) | 0.11 |
ORs, 95% CIs, and p-values result from logistic regression models adjusted for age and gender. ORs correspond to an additional minor allele (additive models), presence of the minor allele (dominant models), and presence of two copies of the minor allele (recessive models). N/A is given for variants with no homozygotes of the minor allele in either patients with PD or controls. MAF=minor allele frequency; OR=odds ratio; CI=confidence interval.