Table 1.
Developmental and reproductive anomalies associated with p53 loss
|
Anomalies |
Stage |
Stress |
Background |
Molecular |
References |
|---|---|---|---|---|---|
| mechanism | |||||
| Implantation failure |
Pre-implantation |
Physiological |
C57BL/6 J (more severe), 129/Sv and Mix |
p53 regulates Lif |
Hu, et al., Nature, 2007 |
| Exencephaly |
Embryonic |
Physiological |
129 (more severe), C57BL/6 |
Unclear |
Armstrong, et al., Curr. Biol., 1995; Sah, et al., Nature Genetics, 1995 |
| Renal hypoplasia |
Embryonic |
Physiological |
C57BL/6 |
p53 regulates Pax2 |
Saifudeen, et al., Plos One, 2012 |
| Polydactyly, megadactyly |
Fetuses |
X-ray |
129/SvJ |
Unclear |
Norimura, et al., Nature Medicine, 1996 |
| Tail anomaly |
Fetuses |
X-ray |
129/SvJ |
Unclear |
Norimura, et al., Nature Medicine, 1996 |
| Muscle |
Adult |
Physiological |
Unknown |
Unclear |
Molchadsky, et al., Plos One, 2008 |
| Testis | Adult | Physiological | 129 (100% penetrance), C57BL/6X129 mix background is normal | Unclear | Rotter, et al., PNAS, 1993 |