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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: Immunity. 2013 Oct 24;39(5):10.1016/j.immuni.2013.10.006. doi: 10.1016/j.immuni.2013.10.006

Figure 3. bvPLA2-induced Th2 responses are dependent upon MyD88 and the IL-33-receptor (ST2).

Figure 3

(A–C) Cytokine production after in vitro restimulation of LN CD4+ T cells from (A) BALB/c and Myd88−/− BALB/c (B) C57Bl/6, Myd88−/− C57Bl/6, Tlr2−/−;Tlr4−/−, Tlr9−/−, Myd88−/−;Trif−/−, Il1r1−/−, and Il18r1−/−, and (C) C57Bl/6 and Il1rl1−/− (ST2-deficient) mice 5 days after immunization with OVA and bvPLA2. (D) Cytokine production after in vitro restimulation of LN CD4+ T cells from C57Bl/6 and Il1rl1−/− mice 5 days after immunization with OVA with or without LPC. (E) Cytokine production after in vitro restimulation of LN CD4+ T cells from C57Bl/6 and MyD88fl/fl;Cd4-Cre mice 5 days after immunization with OVA and bvPLA2. All error bars show s.e.m. N.S. P>.05; *P<0.05; ***P<0.001. Data are representative of at least three experiments.