Table 4.
Results for association tests for imputed common variants in WNT4 genotyped in 930 endometriosis cases and 959 controls
| Variants | Location (Hg19) | Role | N_variant | MAF | MAF in cases | MAF in controls | P value | OR |
|---|---|---|---|---|---|---|---|---|
| rs61768001 | 22465820 | Intron 1-2 | C/T | 0.234# | 0.202 | 0.156 | 2.002 x10-4 | 1.38 (1.16-1.63) |
| rs12037376 | 22462111 | Intron 1-2 | A/G | 0.224# | 0.201 | 0.156 | 2.735 x10-4 | 1.37 (1.15-1.61) |
| rs56318008 | 22470407 | Promoter | T/C | 0.220# | 0.190 | 0.147 | 3.860 x10-4 | 1.36 (1.15-1.62) |
| rs55938609 | 22470451 | Promoter | C/G | 0.230# | 0.190 | 0.148 | 4.730 x10-4 | 1.36 (1.14-1.61) |
| rs7412010 | 22436446 | 3’ near gene | C/G | 0.186* | 0.203 | 0.160 | 7.696 x10-4 | 1.33 (1.13-1.57) |
| rs7521902 | 22490724 | Genomic | A/C | 0.235* | 0.267 | 0.241 | 0.067 | 1.15 (0.99-1.33) |
*
MAF estimate from HapMap CEU population (HapMap data release 28; phase 1, 2 & 3; August 10).
#
MAF estimate from phase 1 data from 1000 Genomes.