Table 1.
Association between common sequence variants in chemokine-related genes and breast cancer risk in postmenopausal women
| Controls | Cases | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| Gene | Variant | Function | Genotype | N=807 | (%) | N=845 | (%) | OR* | (95% CI)* | P-value# |
| CXCR4 | 0.22 | |||||||||
| rs2228014 | Synonymous | 0.70 | (0.47-1.06) | |||||||
| CC | 689 | (92.24) | 723 | (94.39) | ||||||
| TC | 56 | (7.50) | 43 | (5.61) | ||||||
| TT | 2 | (0.27) | 0 | (0.00) | ||||||
| rs2680880 | 5’UTR | 1.04 | (0.91-1.19) | |||||||
| TT | 259 | (32.33) | 267 | (31.79) | ||||||
| AT | 388 | (48.44) | 397 | (47.26) | ||||||
| AA | 154 | (19.23) | 176 | (20.95) | ||||||
| rs2471859 | Intron | 0.88 | (0.75-1.03) | |||||||
| AA | 451 | (56.30) | 507 | (60.36) | ||||||
| AG | 300 | (37.45) | 285 | (33.93) | ||||||
| GG | 50 | (6.24) | 48 | (5.71) | ||||||
| CCL20 | 0.32 | |||||||||
| rs6749704 | Flanking 5’UTR | 0.92 | (0.79-1.07) | |||||||
| AA | 385 | (48.06) | 430 | (51.19) | ||||||
| AG | 347 | (43.32) | 339 | (40.36) | ||||||
| GG | 69 | (8.61) | 71 | (8.45) | ||||||
| rs940339 | Flanking 3’UTR | 1.09 | (0.95-1.25) | |||||||
| AA | 203 | (25.37) | 210 | (25.00) | ||||||
| AG | 415 | (51.88) | 405 | (48.21) | ||||||
| GG | 182 | (22.75) | 225 | (26.79) | ||||||
| CCR5 | 0.85 | |||||||||
| rs11575816 | Flanking 3’UTR | 0.99 | (0.86-1.14) | |||||||
| GG | 318 | (39.7) | 340 | (40.48) | ||||||
| AG | 376 | (46.94) | 387 | (46.07) | ||||||
| AA | 107 | (13.36) | 113 | (13.45) | ||||||
| CCR6 | 0.57 | |||||||||
| rs3093027 | Flanking 5’UTR | 1.22 | (0.94-1.59) | |||||||
| AA | 682 | (85.14) | 692 | (82.48) | ||||||
| AC | 112 | (13.98) | 144 | (17.16) | ||||||
| CC | 7 | (0.87) | 3 | (0.36) | ||||||
| rs3093026 | Flanking 5’UTR | 0.92 | (0.8-1.05) | |||||||
| GG | 215 | (26.84) | 235 | (28.01) | ||||||
| AG | 388 | (48.44) | 422 | (50.30) | ||||||
| AA | 198 | (24.72) | 182 | (21.69) | ||||||
| rs3093023 | Flanking 5’UTR | 1.04 | (0.9-1.19) | |||||||
| GG | 274 | (34.21) | 263 | (31.31) | ||||||
| AG | 368 | (45.94) | 420 | (50.00) | ||||||
| AA | 159 | (19.85) | 157 | (18.69) | ||||||
| rs3798315 | Intron | 1.05 | (0.85-1.3) | |||||||
| GG | 639 | (79.78) | 664 | (79.05) | ||||||
| AG | 150 | (18.73) | 162 | (19.29) | ||||||
| AA | 12 | (1.50) | 14 | (1.67) | ||||||
| rs3093012 | Intron | 1.01 | (0.88-1.16) | |||||||
| GG | 271 | (33.83) | 279 | (33.21) | ||||||
| AG | 390 | (48.69) | 415 | (49.40) | ||||||
| AA | 140 | (17.48) | 146 | (17.38) | ||||||
| rs3093010 | Intron | 1.00 | (0.86-1.15) | |||||||
| CC | 365 | (45.57) | 375 | (44.64) | ||||||
| AC | 336 | (41.95) | 369 | (43.93) | ||||||
| AA | 100 | (12.48) | 96 | (11.43) | ||||||
| rs3093007 | Synonymous | 0.93 | (0.78-1.11) | |||||||
| AA | 534 | (66.67) | 577 | (68.69) | ||||||
| AG | 239 | (29.84) | 234 | (27.86) | ||||||
| GG | 28 | (3.50) | 29 | (3.45) | ||||||
| rs3093006 | 3’UTR | 1.06 | (0.87-1.3) | |||||||
| GG | 608 | (75.91) | 625 | (74.40) | ||||||
| AG | 179 | (22.35) | 201 | (23.93) | ||||||
| AA | 14 | (1.75) | 14 | (1.67) | ||||||
| rs3093005 | 3’UTR | 1.04 | (0.64-1.7) | |||||||
| AA | 768 | (96.00) | 805 | (95.83) | ||||||
| AG | 32 | (4.00) | 35 | (4.17) | ||||||
| GG | 0 | (0.00) | 0 | (0.00) | ||||||
| rs11575083 | 3’UTR | 0.99 | (0.58-1.67) | |||||||
| GG | 773 | (96.50) | 811 | (96.55) | ||||||
| AG | 28 | (3.50) | 29 | (3.45) | ||||||
| AA | 0 | (0.00) | 0 | (0.00) | ||||||
| rs3093002 | Flanking 3’UTR | 0.90 | (0.78-1.05) | |||||||
| GG | 355 | (44.38) | 395 | (47.08) | ||||||
| AG | 371 | (46.38) | 378 | (45.05) | ||||||
| AA | 74 | (9.25) | 66 | (7.87) | ||||||
| rs3093001 | Flanking 3’UTR | 1.13 | (0.98-1.29) | |||||||
| AA | 208 | (26.10) | 194 | (23.23) | ||||||
| AC | 399 | (50.06) | 416 | (49.82) | ||||||
| CC | 190 | (23.84) | 225 | (26.95) | ||||||
| rs367523 | Flanking 3’UTR | 0.92 | (0.8-1.06) | |||||||
| CC | 303 | (37.83) | 334 | (39.76) | ||||||
| CG | 392 | (48.94) | 410 | (48.81) | ||||||
| GG | 106 | (13.23) | 96 | (11.43) | ||||||
| rs4710189 | Flanking 3’UTR | 0.92 | (0.8-1.07) | |||||||
| AA | 340 | (42.45) | 377 | (44.88) | ||||||
| AG | 374 | (46.69) | 380 | (45.24) | ||||||
| GG | 87 | (10.86) | 83 | (9.88) | ||||||
| CXCL12 | 0.68 | |||||||||
| rs266093 | 3’UTR | 1.07 | (0.93-1.24) | |||||||
| GG | 299 | (40.46) | 304 | (39.79) | ||||||
| GC | 338 | (45.74) | 333 | (43.59) | ||||||
| CC | 102 | (13.8) | 127 | (16.62) | ||||||
| rs1029153 | 3’UTR | 0.91 | (0.79-1.05) | |||||||
| AA | 391 | (48.81) | 427 | (50.89) | ||||||
| AG | 322 | (40.20) | 337 | (40.17) | ||||||
| GG | 88 | (10.99) | 75 | (8.94) | ||||||
| rs1801157 | 3’UTR | 1.04 | (0.87-1.23) | |||||||
| GG | 515 | (64.29) | 523 | (62.26) | ||||||
| AG | 251 | (31.34) | 288 | (34.29) | ||||||
| AA | 35 | (4.37) | 29 | (3.45) | ||||||
| rs266087 | Intron | 0.93 | (0.81-1.08) | |||||||
| GG | 325 | (40.68) | 360 | (42.91) | ||||||
| AG | 371 | (46.43) | 378 | (45.05) | ||||||
| AA | 103 | (12.89) | 101 | (12.04) | ||||||
| rs2839695 | 3’UTR | 1.07 | (0.91-1.27) | |||||||
| AA | 504 | (62.92) | 528 | (62.86) | ||||||
| AG | 270 | (33.71) | 264 | (31.43) | ||||||
| GG | 27 | (3.37) | 48 | (5.71) | ||||||
| rs2236534 | Intron | 0.98 | (0.83-1.16) | |||||||
| CC | 493 | (61.55) | 530 | (63.10) | ||||||
| AC | 276 | (34.46) | 268 | (31.90) | ||||||
| AA | 32 | (4.00) | 42 | (5.00) | ||||||
| rs3780891 | Intron | 0.90 | (0.71-1.13) | |||||||
| GG | 647 | (80.77) | 692 | (82.38) | ||||||
| AG | 144 | (17.98) | 140 | (16.67) | ||||||
| AA | 10 | (1.25) | 8 | (0.95) | ||||||
| CCL5 | 0.62 | |||||||||
| rs2107538 | Flanking 5’UTR | 0.95 | (0.8-1.14) | |||||||
| GG | 541 | (67.54) | 590 | (70.24) | ||||||
| AG | 240 | (29.96) | 218 | (25.95) | ||||||
| AA | 20 | (2.50) | 32 | (3.81) | ||||||
| CCL3 | 0.93 | |||||||||
| rs9972960 | Flanking 5’UTR | 1.00 | (0.87-1.16) | |||||||
| GG | 307 | (38.33) | 330 | (39.29) | ||||||
| AG | 395 | (49.31) | 398 | (47.38) | ||||||
| AA | 99 | (12.36) | 112 | (13.33) | ||||||
| rs1634502 | Flanking 5’UTR | 0.98 | (0.85-1.12) | |||||||
| AA | 286 | (35.75) | 294 | (35.00) | ||||||
| AT | 372 | (46.50) | 412 | (49.05) | ||||||
| TT | 142 | (17.75) | 134 | (15.95) | ||||||
| CCL4 | 0.92 | |||||||||
| rs10491121 | Flanking 5’UTR | 0.97 | (0.85-1.11) | |||||||
| GG | 288 | (35.96) | 298 | (35.48) | ||||||
| AG | 368 | (45.94) | 406 | (48.33) | ||||||
| AA | 145 | (18.10) | 136 | (16.19) | ||||||
| rs1634517 | Intron | 1.05 | (0.89-1.24) | |||||||
| CC | 472 | (59.97) | 492 | (59.78) | ||||||
| AC | 282 | (35.83) | 284 | (34.51) | ||||||
| AA | 33 | (4.19) | 47 | (5.71) | ||||||
| rs17679451 | Flanking 3’UTR | 1.03 | (0.72-1.47) | |||||||
| GG | 736 | (91.89) | 770 | (91.67) | ||||||
| AG | 63 | (7.87) | 68 | (8.10) | ||||||
| AA | 2 | (0.25) | 2 | (0.24) | ||||||
| rs1619526 | Flanking 3’UTR | 1.05 | (0.89-1.24) | |||||||
| GG | 472 | (58.93) | 492 | (58.57) | ||||||
| AG | 292 | (36.45) | 297 | (35.36) | ||||||
| AA | 37 | (4.62) | 51 | (6.07) | ||||||
*
Odds ratios (ORs) and 95% confidence intervals (CI) are computed using a multiplicative model (additive on log scale).
If genotype counts were less than 5 for any of the three cells, a dominant model was used. ORs and 95% CI are age adjusted (age as a continuous linear variable).
#
P-value adjusted for multiple comparisons within a gene using a P-min permutation test.