Table 2.
Association between common sequence variants in chemokine-related genes and breast cancer risk in postmenopausal women by tumor subtypes
| Controls (N=807) | Luminal Cases (N=744) | Non-luminal Cases (N=73) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||||||
| Gene | Variant | Genotype | n | (%) | n | (%) | OR* | (95% CI)* | P-value# | n | (%) | OR* | (95% CI)* | P-value# |
| CXCR4 | 0.08 | 0.75 | ||||||||||||
| rs2228014 | 0.61 | (0.39-0.95) | 1.28 | (0.56-2.93) | ||||||||||
| CC | 689 | (92.24) | 639 | (95.09) | 62 | (89.86) | ||||||||
| TC | 56 | (7.50) | 33 | (4.91) | 7 | (10.14) | ||||||||
| TT | 2 | (0.27) | 0 | (0.00) | 0 | (0.00) | ||||||||
| rs2680880 | 1.02 | (0.89-1.18) | 1.04 | (0.74-1.47) | ||||||||||
| TT | 259 | (32.33) | 243 | (32.88) | 19 | (26.03) | ||||||||
| AT | 388 | (48.44) | 341 | (46.14) | 43 | (58.90) | ||||||||
| AA | 154 | (19.23) | 155 | (20.97) | 11 | (15.07) | ||||||||
| rs2471859 | 0.91 | (0.77-1.07) | 0.80 | (0.49-1.31) | ||||||||||
| AA | 451 | (56.30) | 440 | (59.54) | 45 | (61.64) | ||||||||
| AG | 300 | (37.45) | 255 | (34.51) | 26 | (35.62) | ||||||||
| GG | 50 | (6.24) | 44 | (5.95) | 2 | (2.74) | ||||||||
| CCL20 | 0.22 | 0.28 | ||||||||||||
| rs6749704 | 0.91 | (0.78-1.06) | 1.11 | (0.77-1.6) | ||||||||||
| AA | 385 | (48.06) | 380 | (51.42) | 35 | (47.95) | ||||||||
| AG | 347 | (43.32) | 299 | (40.46) | 29 | (39.73) | ||||||||
| GG | 69 | (8.61) | 60 | (8.12) | 9 | (12.33) | ||||||||
| rs940339 | 1.12 | (0.97-1.29) | 0.79 | (0.55-1.11) | ||||||||||
| AA | 203 | (25.37) | 181 | (24.49) | 24 | (32.88) | ||||||||
| AG | 415 | (51.88) | 356 | (48.17) | 35 | (47.95) | ||||||||
| GG | 182 | (22.75) | 202 | (27.33) | 14 | (19.18) | ||||||||
| CCR5 | 0.93 | 0.77 | ||||||||||||
| rs11575816 | 0.99 | (0.86-1.15) | 0.95 | (0.67-1.35) | ||||||||||
| GG | 318 | (39.70) | 294 | (39.78) | 32 | (43.84) | ||||||||
| AG | 376 | (46.94) | 348 | (47.09) | 30 | (41.1) | ||||||||
| AA | 107 | (13.36) | 97 | (13.13) | 11 | (15.07) | ||||||||
| CCR6 | 0.51 | 1.00 | ||||||||||||
| rs3093027 | 1.22 | (0.93-1.60) | 1.05 | (0.53-2.05) | ||||||||||
| AA | 682 | (85.14) | 609 | (82.52) | 62 | (84.93) | ||||||||
| AC | 112 | (13.98) | 126 | (17.07) | 11 | (15.07) | ||||||||
| CC | 7 | (0.87) | 3 | (0.41) | 0 | (0) | ||||||||
| rs3093026 | 0.91 | (0.79-1.05) | 0.92 | (0.65-1.28) | ||||||||||
| GG | 215 | (26.84) | 210 | (28.46) | 20 | (27.4) | ||||||||
| AG | 388 | (48.44) | 369 | (50.00) | 37 | (50.68) | ||||||||
| AA | 198 | (24.72) | 159 | (21.54) | 16 | (21.92) | ||||||||
| rs3093023 | 1.05 | (0.92-1.21) | 1.05 | (0.75-1.47) | ||||||||||
| GG | 274 | (34.21) | 228 | (30.85) | 22 | (30.14) | ||||||||
| AG | 368 | (45.94) | 370 | (50.07) | 38 | (52.05) | ||||||||
| AA | 159 | (19.85) | 141 | (19.08) | 13 | (17.81) | ||||||||
| rs3798315 | 1.09 | (0.87-1.35) | 0.86 | (0.46-1.61) | ||||||||||
| GG | 639 | (79.78) | 579 | (78.35) | 60 | (82.19) | ||||||||
| AG | 150 | (18.73) | 147 | (19.89) | 13 | (17.81) | ||||||||
| AA | 12 | (1.50) | 13 | (1.76) | 0 | (0) | ||||||||
| rs3093012 | 1.02 | (0.89-1.18) | 0.95 | (0.67-1.34) | ||||||||||
| GG | 271 | (33.83) | 242 | (32.75) | 26 | (35.62) | ||||||||
| AG | 390 | (48.69) | 368 | (49.80) | 35 | (47.95) | ||||||||
| AA | 140 | (17.48) | 129 | (17.46) | 12 | (16.44) | ||||||||
| rs3093010 | 1.02 | (0.88-1.18) | 0.91 | (0.64-1.31) | ||||||||||
| CC | 365 | (45.57) | 324 | (43.84) | 34 | (46.58) | ||||||||
| AC | 336 | (41.95) | 328 | (44.38) | 32 | (43.84) | ||||||||
| AA | 100 | (12.48) | 87 | (11.77) | 7 | (9.59) | ||||||||
| rs3093007 | 0.92 | (0.77-1.11) | 0.94 | (0.57-1.58) | ||||||||||
| AA | 534 | (66.67) | 510 | (69.01) | 49 | (67.12) | ||||||||
| AG | 239 | (29.84) | 203 | (27.47) | 23 | (31.51) | ||||||||
| GG | 28 | (3.50) | 26 | (3.52) | 1 | (1.37) | ||||||||
| rs3093006 | 1.04 | (0.85-1.29) | 1.17 | (0.68-2.01) | ||||||||||
| GG | 608 | (75.91) | 551 | (74.56) | 53 | (72.6) | ||||||||
| AG | 179 | (22.35) | 178 | (24.09) | 18 | (24.66) | ||||||||
| AA | 14 | (1.75) | 10 | (1.35) | 2 | (2.74) | ||||||||
| rs3093005 | 0.98 | (0.59-1.64) | 1.04 | (0.31-3.51) | ||||||||||
| AA | 768 | (96.00) | 710 | (96.08) | 70 | (95.89) | ||||||||
| AG | 32 | (4.00) | 29 | (3.92) | 3 | (4.11) | ||||||||
| GG | 0 | (0.00) | 0 | (0.00) | 0 | (0) | ||||||||
| rs11575083 | 0.89 | (0.51-1.55) | 1.2 | (0.35-4.05) | ||||||||||
| GG | 773 | (96.50) | 716 | (96.89) | 70 | (95.89) | ||||||||
| AG | 28 | (3.50) | 23 | (3.11) | 3 | (4.11) | ||||||||
| AA | 0 | (0.00) | 0 | (0) | 0 | (0) | ||||||||
| rs3093002 | 0.90 | (0.77-1.05) | 1.07 | (0.74-1.55) | ||||||||||
| GG | 355 | (44.38) | 347 | (47.02) | 33 | (47.02) | ||||||||
| AG | 371 | (46.38) | 335 | (45.39) | 31 | (42.47) | ||||||||
| AA | 74 | (9.25) | 56 | (7.59) | 9 | (12.33) | ||||||||
| rs3093001 | 1.14 | (0.99-1.31) | 1.00 | (0.71-1.4) | ||||||||||
| AA | 208 | (26.1) | 170 | (23.16) | 17 | (23.29) | ||||||||
| AC | 399 | (50.06) | 363 | (49.46) | 41 | (56.16) | ||||||||
| CC | 190 | (23.84) | 201 | (27.38) | 15 | (20.55) | ||||||||
| rs367523 | 0.90 | (0.77-1.05) | 1.15 | (0.81-1.63) | ||||||||||
| CC | 303 | (37.83) | 294 | (39.78) | 28 | (38.36) | ||||||||
| CG | 392 | (48.94) | 367 | (49.66) | 31 | (42.47) | ||||||||
| GG | 106 | (13.23) | 78 | (10.55) | 14 | (19.18) | ||||||||
| rs4710189 | 0.92 | (0.79-1.08) | 1.02 | (0.71-1.47) | ||||||||||
| AA | 340 | (42.45) | 329 | (44.52) | 34 | (46.58) | ||||||||
| AG | 374 | (46.69) | 340 | (46.01) | 28 | (38.36) | ||||||||
| GG | 87 | (10.86) | 70 | (9.47) | 11 | (15.07) | ||||||||
| CXCL12 | 0.69 | 0.45 | ||||||||||||
| rs266093 | 1.06 | (0.91-1.23) | 1.07 | (0.75-1.54) | ||||||||||
| GG | 299 | (40.46) | 272 | (40.54) | 24 | (35.29) | ||||||||
| GC | 338 | (45.74) | 286 | (42.62) | 36 | (52.94) | ||||||||
| CC | 102 | (13.8) | 113 | (16.84) | 8 | (11.76) | ||||||||
| rs1029153 | 0.94 | (0.80-1.09) | 0.81 | (0.56-1.18) | ||||||||||
| AA | 391 | (48.81) | 370 | (50.14) | 39 | (53.42) | ||||||||
| AG | 322 | (40.2) | 299 | (40.51) | 29 | (39.73) | ||||||||
| GG | 88 | (10.99) | 69 | (9.35) | 5 | (6.85) | ||||||||
| rs1801157 | 1.03 | (0.87-1.24) | 1.05 | (0.64-1.73) | ||||||||||
| GG | 515 | (64.29) | 459 | (62.11) | 46 | (63.01) | ||||||||
| AG | 251 | (31.34) | 256 | (34.64) | 25 | (34.25) | ||||||||
| AA | 35 | (4.37) | 24 | (3.25) | 2 | (2.74) | ||||||||
| rs266087 | 0.91 | (0.78-1.06) | 1.14 | (0.8-1.62) | ||||||||||
| GG | 325 | (40.68) | 325 | (44.04) | 24 | (32.88) | ||||||||
| AG | 371 | (46.43) | 325 | (44.04) | 41 | (56.16) | ||||||||
| AA | 103 | (12.89) | 88 | (11.92) | 8 | (10.96) | ||||||||
| rs2839695 | 1.07 | (0.90-1.27) | 1.25 | (0.83-1.88) | ||||||||||
| AA | 504 | (62.92) | 466 | (63.06) | 43 | (58.9) | ||||||||
| AG | 270 | (33.71) | 231 | (31.26) | 25 | (34.25) | ||||||||
| GG | 27 | (3.37) | 42 | (6.68) | 5 | (6.85) | ||||||||
| rs2236534 | 1.04 | (0.88-1.24) | 0.65 | (0.38-1.1) | ||||||||||
| CC | 493 | (61.55) | 456 | (61.71) | 52 | (71.23) | ||||||||
| AC | 276 | (34.46) | 242 | (32.75) | 20 | (27.4) | ||||||||
| AA | 32 | (4) | 41 | (5.55) | 1 | (1.37) | ||||||||
| rs3780891 | 0.86 | (0.68-1.09) | 1.2 | (0.67-2.15) | ||||||||||
| GG | 647 | (80.77) | 615 | (83.22) | 57 | (78.08) | ||||||||
| AG | 144 | (17.98) | 116 | (15.70) | 16 | (21.92) | ||||||||
| AA | 10 | (1.25) | 8 | (1.08) | 0 | (0) | ||||||||
| CCL5 | 0.56 | 0.63 | ||||||||||||
| rs2107538 | 0.94 | (0.78-1.14) | 1.12 | (0.72-1.73) | ||||||||||
| GG | 541 | (67.54) | 520 | (70.37) | 50 | (68.49) | ||||||||
| AG | 240 | (29.96) | 192 | (25.98) | 18 | (24.66) | ||||||||
| AA | 20 | (2.5) | 27 | (3.65) | 5 | (6.85) | ||||||||
| CCL3 | 0.99 | 0.10 | ||||||||||||
| rs9972960 | 0.99 | (0.85-1.15) | 1.03 | (0.72-1.49) | ||||||||||
| GG | 307 | (38.33) | 296 | (40.05) | 25 | (34.25) | ||||||||
| AG | 395 | (49.31) | 342 | (46.28) | 41 | (56.16) | ||||||||
| AA | 99 | (12.36) | 101 | (13.67) | 7 | (9.59) | ||||||||
| rs1634502 | 1.01 | (0.87-1.16) | 0.71 | (0.5-1.01) | ||||||||||
| AA | 286 | (35.75) | 251 | (49.80) | 33 | (45.21) | ||||||||
| AT | 372 | (46.5) | 368 | (16.24) | 32 | (43.84) | ||||||||
| TT | 142 | (17.75) | 120 | (34.51) | 8 | (10.96) | ||||||||
| CCL4 | 0.97 | 0.06 | ||||||||||||
| rs10491121 | 1.00 | (0.87-1.15) | 0.68 | (0.48-0.98) | ||||||||||
| GG | 288 | (35.96) | 255 | (34.51) | 33 | (45.21) | ||||||||
| AG | 368 | (45.94) | 361 | (48.85) | 33 | (45.21) | ||||||||
| AA | 145 | (18.1) | 123 | (16.64) | 7 | (9.59) | ||||||||
| rs1634517 | 1.02 | (0.86-1.22) | 1.57 | (1.07-2.32) | ||||||||||
| CC | 472 | (59.97) | 437 | (60.36) | 35 | (49.3) | ||||||||
| AC | 282 | (35.83) | 248 | (34.25) | 29 | (40.85) | ||||||||
| AA | 33 | (4.19) | 39 | (5.39) | 7 | (9.86) | ||||||||
| rs17679451 | 1.06 | (0.73-1.52) | 0.99 | (0.41-2.36) | ||||||||||
| GG | 736 | (91.89) | 676 | (91.47) | 67 | (91.78) | ||||||||
| AG | 63 | (7.87) | 61 | (8.25) | 6 | (8.22) | ||||||||
| AA | 2 | (0.25) | 2 | (0.27) | 0 | (0) | ||||||||
| rs1619526 | 1.04 | (0.88-1.23) | 1.39 | (0.95-2.05) | ||||||||||
| GG | 472 | (58.93) | 435 | (58.86) | 37 | (50.68) | ||||||||
| AG | 292 | (36.45) | 261 | (35.32) | 30 | (41.1) | ||||||||
| AA | 37 | (4.62) | 43 | (5.82) | 6 | (8.22) | ||||||||
*
Odds ratios (ORs) and 95% CI intervals (CI) are adjusted for age.
If genotype counts were less than 5 for any of the three cells, a dominant model was used; otherwise, an additive model was used.
#
P-value adjusted for multiple comparisons within a gene using a P-min permutation test.