Table 3.
LHR and LHRH genotypes among PC cases and controls
| All Races | Whites | African Americans | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Controls | Cases | OR (95% CI) | Controls | Cases | OR (95% CI) | Controls | Cases | OR (95% CI) | |
| Genotype | |||||||||
| LHR321 | |||||||||
| AA | 115 (20%) | 283 (26%) | 1.00 (ref) | 45 (11%) | 114 (15%) | 1.00 (ref) | 70 (45%) | 169 (52%) | 1.00 (ref) |
| AG | 272 (47%) | 466 (43%) | 0.70 (0.54, 0.93) | 204 (48%) | 339 (44%) | 0.65 (0.32, 0.97) | 68 (44%) | 127 (39%) | 0.78 (0.51, 1.17) |
| GG | 187 (33%) | 340 (31%) | 0.68 (0.49, 0.93) | 170 (41%) | 309 (41%) | 0.63 (0.32, 0.96) | 17 (11%) | 31 (9%) | 0.75 (0.38, 1.46) |
| 574 (100%) | 1089 (100%) | 419 (100%) | 762 (100%) | 155 (100%) | 327 (100%) | ||||
| LHRH16 | |||||||||
| GG | 360 (66%) | 757 (69%) | 1.00 (ref) | 241 (61%) | 471 (62%) | 1.00 (ref) | 119 (80%) | 286 (85%) | 1.00 (ref) |
| GC | 159 (30%) | 295 (27%) | 0.93 (0.73, 1.19) | 130 (35%) | 248 (32%) | 0.97 (0.73, 1.28) | 29 (19%) | 47 (14%) | 0.78 (0.46, 1.32) |
| CC | 19 (4%) | 46 (4%) | 1.21 (0.68, 2.16) | 18 (5%) | 44 (6%) | 1.26 (0.69, 2.29) | 1 (1%) | 2 (1%) | 0.47 (0.04, 5.32) |
| 538 (100%) | 1098 (100%) | 389 (100%) | 763 (100%) | 149 (100%) | 335 (100%) | ||||
Odds ratios calculated from conditional logistic regression, adjusting for age, 1st degree family history of PC, race/ethnicity, and SES.