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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Ann N Y Acad Sci. 2013 Aug 27;1302(1):10.1111/nyas.12258. doi: 10.1111/nyas.12258

Figure 1.

Figure 1

Dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) modulation of brown/white adipocyte formation and thermogenesis through the sympathetic nervous system (SNS). Knockdown of NPY in the DMH elevates thermogenic activity of interscapular brown adipose tissue. DMH NPY knockdown promotes the development of brown adipocytes (likely brite/beige cells) in the inguinal white adipose tissue and increases fat thermogenesis. A complete DMH NPY signaling pathway remains to be determined (indicated as a dashed line with arrow head).