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A case of a human papillomavirus (HPV)-16-positive, estrogen receptor (ER)-negative breast metaplastic carcinoma with chondroid differentiation, is illustrated (Case 1). Note the absence of brown colouration in the neoplastic cell nuclei, indicating the lack of ER immunoreactivity (anti-ER antibody, clone1D5). (Immunohistochemistry [IHC]; Original magnification 200×).
