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. Author manuscript; available in PMC: 2014 Oct 22.
Published in final edited form as: Biochemistry. 2013 Oct 7;52(42):10.1021/bi401195r. doi: 10.1021/bi401195r

Figure 1.

Figure 1

AlkD traps the lesion away from the protein. (A) Crystal structure of human alkyladenine DNA glycosylase (AAG) in complex with 1,N6-ethenoadenine (εA)-DNA. (B,C) Crystal structures of AlkD in complex with (B) 3-deaza-3-methyladenine (3d3mA)-DNA and (C) tetrahydrofuran (THF)-DNA. The modified base pairs are rendered as CPK spheres, with εA, 3d3mA and THF in green and the opposing thymidine in magenta. (D) Side view of the extrahelical THF-T bulge trapped by AlkD (blue).