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The effect of GW3965 on CXCL10 mRNA expression in LPS stimulated alveolar macrophages. Macrophages from smoking controls (A) (n=8) and COPD patients (B) (n=8) were treated with vehicle (DMSO 0.05%) or GW3965 (1 μM or 10 μM) for 1 h prior to LPS (1 μg/ml) stimulation for 6 h. Data shown are median ± range of fold change. ** = significant difference compared to time matched control (p<0.01 respectively). ns=non-significant.
