Table 2.
Association of body size and breast cancer risk in women of African ancestry, Women’s Circle of Health Study
| |
Pre-menopausal |
Post-menopausal |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
|
Current BMI* |
|
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
102/103 |
Ref |
|
Ref |
|
74/68 |
Ref |
|
Ref |
|
| Overweight (25–29.99) |
150/142 |
1.02 |
0.70–1.49 |
1.05 |
0.70–1.57 |
131/132 |
0.93 |
0.60–1.44 |
0.93 |
0.59–1.47 |
| Obese (≥30) |
217/237 |
0.89 |
0.61–1.28 |
0.92 |
0.54–1.56 |
304/276 |
0.98 |
0.66–1.45 |
1.00 |
0.58–1.72 |
| p for trend |
|
|
0.40 |
|
0.65 |
|
|
0.94 |
|
0.86 |
|
Current BMI* |
|
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
102/103 |
Ref |
|
Ref |
|
74/68 |
Ref |
|
Ref |
|
| Pre–obese (25–29.99) |
150/142 |
1.01 |
0.69–1.48 |
0.98 |
0.64–1.49 |
131/132 |
0.93 |
0.60–1.44 |
0.88 |
0.55–1.41 |
| Obese Class I (30–34.99) |
111/94 |
1.06 |
0.70–1.61 |
0.93 |
0.54–1.62 |
146/121 |
1.08 |
0.70–1.68 |
0.98 |
0.56–1.72 |
| Obese Class II (35–39.99) |
50/68 |
0.71 |
0.43–1.17 |
0.62 |
0.31–1.26 |
94/89 |
0.90 |
0.56–1.44 |
0.80 |
0.41–1.58 |
| Obese Class III (≥40) |
56/75 |
0.79 |
0.49–1.29 |
0.64 |
0.26–1.56 |
64/66 |
0.89 |
0.53–1.48 |
0.74 |
0.31–1.78 |
| p for trend |
|
|
0.17 |
|
0.20 |
|
|
0.65 |
|
0.47 |
|
BMI one year before reference date** |
|
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
115/113 |
Ref |
|
Ref |
|
66/77 |
Ref |
|
Ref |
|
| Overweight (25–29.99) |
138/143 |
0.86 |
0.59–1.25 |
0.90 |
0.61–1.33 |
147/140 |
1.27 |
0.82–1.96 |
1.32 |
0.84–2.07 |
| Obese (≥30) |
214/221 |
0.91 |
0.63–1.30 |
1.00 |
0.62–1.62 |
293/254 |
1.27 |
0.85–1.89 |
1.46 |
0.87–2.44 |
| p for trend |
|
|
0.74 |
|
0.88 |
|
|
0.41 |
|
0.22 |
|
BMI one year before reference date** |
|
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
115/113 |
Ref |
|
Ref |
|
66/77 |
Ref |
|
Ref |
|
| Pre-obese (25–29.99) |
138/143 |
0.86 |
0.59–1.25 |
0.87 |
0.58–1.29 |
147/140 |
1.27 |
0.82–1.96 |
1.32 |
0.83–2.08 |
| Obese Class I (30–34.99) |
121/92 |
1.17 |
0.77–1.76 |
1.16 |
0.71–1.90 |
143/129 |
1.23 |
0.79–1.90 |
1.34 |
0.80–2.27 |
| Obese Class II (35–39.99) |
43/73 |
0.55 |
0.33–0.90 |
0.54 |
0.28–1.02 |
87/55 |
1.70 |
1.02–2.82 |
1.97 |
1.02–3.82 |
| Obese Class III (≥40) |
50/56 |
0.93 |
0.56–1.54 |
0.93 |
0.43–2.00 |
63/70 |
0.98 |
0.58–1.64 |
1.19 |
0.55–2.55 |
| p for trend | 0.39 | 0.61 | 0.86 | 0.64 | ||||||
*BMI measured at interview. **Based on self-reported weight one year before reference date and measured height at interview.
OR1: Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity (continuous), breastfeeding (yes/no), age at first birth, HRT use (ever/never), OC use (ever/never). OR2: Further adjusted for waist circumference.