Table 4.
Body composition measures and breast cancer
| |
Pre-menopausal |
Post-menopausal |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
|
Fat mass (kg) |
|
|
|
|
|
|
|
|
|
|
| ≤25.3 |
128/125 |
Ref |
|
Ref |
|
101/102 |
Ref |
|
Ref |
|
| 25.4–34.1 |
131/116 |
1.08 |
0.74–1.56 |
1.24 |
0.82–1.87 |
126/107 |
1.16 |
0.78–1.74 |
1.34 |
0.86–2.07 |
| 34.2–44.3 |
96/100 |
0.92 |
0.62–1.37 |
1.19 |
0.70–2.03 |
124/123 |
0.94 |
0.63–1.40 |
1.21 |
0.72–2.04 |
| >44.3 |
87/114 |
0.82 |
0.54–1.23 |
1.39 |
0.61–3.14 |
120/110 |
1.05 |
0.70–1.57 |
1.69 |
0.82–3.49 |
| p for trend |
|
|
0.24 |
|
0.49 |
|
|
0.93 |
|
0.22 |
|
Fat free mass (kg) |
|
|
|
|
|
|
|
|
|
|
| ≤44.1 |
112/108 |
Ref |
|
Ref |
|
130/118 |
Ref |
|
Ref |
|
| 44.2–48 |
121/125 |
0.94 |
0.64–1.39 |
1.04 |
0.70–1.55 |
134/99 |
1.28 |
0.87–1.88 |
1.32 |
0.88–1.96 |
| 48.1–52.6 |
106/99 |
1.00 |
0.67–1.51 |
1.24 |
0.78–1.98 |
107/124 |
0.87 |
0.59–1.27 |
0.92 |
0.59–1.43 |
| >52.6 |
103/123 |
0.84 |
0.57–1.26 |
1.32 |
0.70–2.47 |
101/101 |
0.96 |
0.65–1.43 |
1.05 |
0.61–1.83 |
| p for trend |
|
|
0.44 |
|
0.35 |
|
|
0.47 |
|
0.88 |
|
Percent body fat |
|
|
|
|
|
|
|
|
|
|
| ≤35.9 |
145/137 |
Ref |
|
Ref |
|
93/94 |
Ref |
|
Ref |
|
| 36–41.6 |
118/118 |
0.92 |
0.64–1.33 |
1.02 |
0.69–1.52 |
123/107 |
1.14 |
0.75–1.71 |
1.27 |
0.83–1.96 |
| 41.7–46.5 |
96/104 |
0.88 |
0.60–1.30 |
1.07 |
0.67–1.72 |
119/124 |
0.85 |
0.57–1.29 |
1.05 |
0.65–1.70 |
| >46.5 |
83/106 |
0.82 |
0.55–1.23 |
1.22 |
0.62–2.42 |
137/119 |
1.09 |
0.73–1.63 |
1.59 |
0.87–2.93 |
| p for trend |
|
|
0.32 |
|
0.65 |
|
|
0.98 |
|
0.26 |
|
Fat mass index |
|
|
|
|
|
|
|
|
|
|
| ≤9.37 |
128/129 |
Ref |
|
– |
– |
86/96 |
Ref |
|
- |
- |
| 9.38–12.78 |
138/119 |
1.09 |
0.75–1.58 |
- |
- |
124/104 |
1.39 |
0.92–2.11 |
- |
- |
| 12.79–16.77 |
93/98 |
0.95 |
0.63–1.42 |
- |
- |
140/127 |
1.13 |
0.75–1.70 |
- |
- |
| >16.77 |
83/109 |
0.80 |
0.53–1.21 |
- |
- |
121/115 |
1.10 |
0.72–1.66 |
- |
- |
| p for trend |
|
|
0.35 |
- |
- |
|
|
0.58 |
- |
- |
|
Fat free mass index |
|
|
|
- |
- |
|
|
|
- |
- |
| ≤16.64 |
126/118 |
Ref |
|
- |
- |
123/106 |
Ref |
|
- |
- |
| 16.65-18.04 |
116/121 |
0.88 |
0.60–1.28 |
- |
- |
108/104 |
0.94 |
0.63–1.40 |
- |
- |
| 18.05–19.80 |
99/99 |
0.85 |
0.57–1.28 |
- |
- |
129/124 |
0.89 |
0.60–1.30 |
- |
- |
| >19.80 |
101/117 |
0.81 |
0.54–1.21 |
- |
- |
112/108 |
0.86 |
0.58–1.28 |
- |
- |
| p for trend | 0.33 | - | - | 0.45 | - | - | ||||
Fat mass index: fat mass in kg/(height in m)2; Fat Free Mass index: fat free mass in kg/(height in m)2 OR1: Adjusted for age, ethnicity, country of origin, education, family history of breast cancer, history of benign breast disease, age at menarche, years since menopause (for postmenopausal women), parity (continuous), breastfeeding (yes/no), age at first birth, HRT use (never/ever), OC use (never/ever). OR2: Further adjusted for BMI.