Table 5.
Association of body size and breast cancer risk among non-HRT users (excluding n = 267 HRT users)
| |
Pre-menopausal |
Post-menopausal |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
|
Current BMI* |
|
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
96/102 |
Ref |
|
Ref |
|
55/53 |
Ref |
|
Ref |
|
| Overweight (25–29.99) |
147/136 |
1.09 |
0.74–1.61 |
1.12 |
0.74–1.69 |
86/107 |
0.76 |
0.46–1.26 |
0.77 |
0.46–1.31 |
| Obese (≥30) |
206/229 |
0.91 |
0.63–1.32 |
0.92 |
0.54–1.58 |
234/218 |
0.97 |
0.62–1.52 |
1.05 |
0.57–1.95 |
| p for trend |
|
|
0.41 |
|
0.60 |
|
|
0.56 |
|
0.49 |
|
% Body Fat |
|
|
|
|
|
|
|
|
|
|
| ≤35.9 |
139/133 |
Ref |
|
Ref |
|
69/73 |
Ref |
|
Ref |
|
| 36–41.6 |
112/114 |
0.90 |
0.62–1.31 |
0.98 |
0.65–1.46 |
85/86 |
1.05 |
0.66–1.68 |
1.18 |
0.72–1.95 |
| 41.7–46.5 |
94/101 |
0.89 |
0.60–1.32 |
1.03 |
0.63–1.66 |
90/95 |
0.87 |
0.54–1.39 |
1.06 |
0.61–1.84 |
| >46.5 |
79/103 |
0.81 |
0.53–1.22 |
1.08 |
0.54–2.17 |
102/96 |
1.03 |
0.65–1.64 |
1.49 |
0.74–2.99 |
| p for trend |
|
|
0.31 |
|
0.88 |
|
|
0.94 |
|
0.38 |
|
Waist to hip ratio |
|
|
|
|
|
|
|
|
|
|
| ≤0.82 |
118/144 |
Ref |
|
Ref |
|
52/70 |
Ref |
|
Ref |
|
| 0.83–0.87 |
122/113 |
1.21 |
0.83–1.77 |
1.27 |
0.87–1.86 |
97/94 |
1.16 |
0.72–1.88 |
1.17 |
0.72–1.90 |
| 0.88–0.92 |
100/116 |
1.02 |
0.69–1.52 |
1.11 |
0.74–1.67 |
78/88 |
0.97 |
0.58–1.59 |
0.99 |
0.60–1.64 |
| >0.92 |
100/90 |
1.22 |
0.80–1.84 |
1.38 |
0.89–2.14 |
140/121 |
1.29 |
0.81–2.06 |
1.34 |
0.83–2.16 |
| p for trend |
|
|
0.51 |
|
0.22 |
|
|
0.35 |
|
0.28 |
|
Waist circumference (cm) |
|
|
|
|
|
|
|
|
|
|
| ≤87.88 |
130/140 |
Ref |
|
Ref |
|
62/75 |
Ref |
|
Ref |
|
| 87.89–97.75 |
120/114 |
1.04 |
0.71–1.50 |
1.25 |
0.83–1.88 |
82/91 |
1.04 |
0.64–1.67 |
1.18 |
0.70–1.97 |
| 97.76–110.25 |
102/112 |
0.94 |
0.64–1.39 |
1.40 |
0.83–2.35 |
114/98 |
1.39 |
0.87–2.20 |
1.74 |
0.99–3.06 |
| >110.25 |
88/97 |
0.98 |
0.64–1.50 |
2.01 |
0.95–4.29 |
109/109 |
1.08 |
0.68–1.72 |
1.64 |
0.77–3.50 |
| p for trend |
|
|
0.84 |
|
0.08 |
|
|
0.61 |
|
0.14 |
|
Hip circumference (cm) |
|
|
|
|
|
|
|
|
|
|
| ≤103.18 |
120/134 |
Ref |
|
Ref |
|
76/81 |
Ref |
|
Ref |
|
| 103.19–111.63 |
129/107 |
1.28 |
0.88–1.86 |
1.60 |
1.06–2.41 |
89/98 |
1.06 |
0.68–1.68 |
1.14 |
0.70–1.86 |
| 111.64–123.15 |
95/113 |
0.97 |
0.65–1.43 |
1.50 |
0.91–2.46 |
112/98 |
1.31 |
0.84–2.04 |
1.47 |
0.85–2.56 |
| >123.15 |
97/109 |
1.10 |
0.74–1.65 |
2.78 |
1.32–5.88 |
90/96 |
0.97 |
0.61–1.54 |
1.22 |
0.56–2.62 |
| p for trend | 0.92 | 0.02 | 0.92 | 0.65 | ||||||
*BMI measured at interview.
OR1: Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity (continuous), breastfeeding (yes/no), age at first birth, OC use (ever/never). OR2: BMI further adjusted for waist circumference. Percent body fat, waist circumference and hip circumference, further adjusted for BMI. Percent body fat adjusted for years since menopause instead of age at menopause.