Table 6.
Association of body size with premenopausal breast cancer by hormone receptor status
| |
|
ER+/PR+ vs. controls |
ER-/PR- vs. controls |
ER-/PR- cases vs. ER+/PR+ cases |
|||||
|---|---|---|---|---|---|---|---|---|---|
| CO | CA | OR | 95% CI | CA | OR | 95% CI | OR | 95% CI | |
|
Current BMI* |
|
|
|
|
|
|
|
|
|
| Underweight/Normal (<25) |
103 |
42 |
Ref |
|
20 |
Ref |
|
Ref |
|
| Overweight (25–29.99) |
142 |
58 |
1.15 |
0.67–1.96 |
31 |
1.17 |
0.59–2.34 |
1.05 |
0.47–2.37 |
| Obese (≥30) |
237 |
95 |
1.34 |
0.68–2.68 |
51 |
1.26 |
0.53–3.00 |
0.88 |
0.30–2.54 |
| p for trend |
|
|
|
0.40 |
|
|
0.65 |
|
0.74 |
|
% Body fat |
|
|
|
|
|
|
|
|
|
| ≤35.9 |
137 |
62 |
Ref |
|
20 |
Ref |
|
Ref |
|
| 36–41.6 |
118 |
51 |
0.99 |
0.59–1.64 |
26 |
1.20 |
0.61–2.34 |
1.23 |
0.58–2.64 |
| 41.7–46.5 |
104 |
43 |
1.10 |
0.59–2.05 |
21 |
1.28 |
0.58–2.86 |
1.17 |
0.47–2.92 |
| >46.5 |
106 |
30 |
0.91 |
0.37–2.24 |
24 |
1.78 |
0.59–5.37 |
1.68 |
0.47–6.08 |
| p for trend |
|
|
|
0.96 |
|
|
0.36 |
|
0.52 |
|
Waist to hip ratio |
|
|
|
|
|
|
|
|
|
| ≤0.82 |
144 |
56 |
Ref |
|
20 |
Ref |
|
Ref |
|
| 0.83–0.87 |
120 |
48 |
0.99 |
0.60–1.63 |
27 |
1.13 |
0.61–2.10 |
1.20 |
0.58–2.49 |
| 0.88–0.92 |
121 |
45 |
1.06 |
0.63–1.78 |
23 |
1.02 |
0.52–2.00 |
0.97 |
0.44–2.15 |
| >0.92 |
93 |
43 |
1.33 |
0.76–2.32 |
24 |
1.51 |
0.74–3.05 |
1.30 |
0.57–3.00 |
| p for trend |
|
|
|
0.33 |
|
|
0.32 |
|
0.63 |
|
Waist circumference (cm) |
|
|
|
|
|
|
|
|
|
| ≤87.88 |
143 |
57 |
Ref |
|
20 |
Ref |
|
Ref |
|
| 87.89–97.75 |
119 |
52 |
1.28 |
0.76–2.17 |
24 |
1.07 |
0.55–2.10 |
0.80 |
0.37–1.75 |
| 97.76–110.25 |
116 |
47 |
1.57 |
0.80–3.08 |
25 |
1.52 |
0.67–3.47 |
0.78 |
0.28–2.16 |
| >110.25 |
100 |
36 |
2.05 |
0.79–5.35 |
23 |
1.91 |
0.59–6.13 |
0.73 |
0.17–3.08 |
| p for trend |
|
|
|
0.13 |
|
|
0.25 |
|
0.67 |
|
Hip circumference (cm) |
|
|
|
|
|
|
|
|
|
| ≤103.18 |
138 |
55 |
Ref |
|
20 |
Ref |
|
Ref |
|
| 103.19–111.63 |
111 |
52 |
1.50 |
0.89–2.54 |
33 |
2.25 |
1.16–4.37 |
1.36 |
0.61–3.00 |
| 111.64–123.15 |
116 |
40 |
1.69 |
0.89–3.20 |
22 |
1.65 |
0.73–3.73 |
0.75 |
0.28–1.99 |
| >123.15 |
113 |
46 |
3.59 |
1.43–9.03 |
24 |
2.60 |
0.79–8.54 |
0.47 |
0.12–1.95 |
| p for trend | 0.01 | 0.22 | 0.15 | ||||||
*BMI measured at interview.
Abbreviations: CO number of controls, CA number of cases, ER estrogen receptor, PR progesterone receptor.
Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, parity (continuous), breastfeeding (yes/no), age at first birth, HRT use (ever/never), OC use (ever/never). BMI also adjusted for waist circumference. Percent body fat, waist circumference, and hip circumference, also adjusted for BMI.