Table 2.
Relative gene expression in aging skeletal muscle
| Age (months) | ||||
|---|---|---|---|---|
| |
6 (n = 16) |
12 (n = 18) |
18 (n = 12) |
24 (n = 12) |
| Gene expression (AU) |
|
|
|
|
| NOX2 |
13.1 ± 2.9 |
11.0 ± 3.1 |
110 ± 14.7abd |
23.0 ± 4.4 |
| p22phox |
17.8 ± 3.7 |
26.5 ±7.0 |
25.1 ± 9.4 |
48.7 ± 10.3 |
| p40phox |
14.0 ± 4.9 |
25.2 ± 8.7 |
57.7 ± 16.9a |
42.9 ± 8.9 |
| p47phox |
3.1 ± 0.6 |
4.8 ± 1.4 |
16.4 ± 7.9 |
4.2 ± 1.2 |
| p67phox |
72.9 ± 13.4 |
41.1 ± 8.9 |
103 ± 33.0 |
272 ± 71abc |
| NOX4 |
1.5 ± 0.3 |
4.3 ± 1.0 |
9.2 ± 3.2a |
5.1 ± 1.3 |
| Rac1 |
1.2 ± 1.1 |
3.91 ± 0.9 |
2.9 ± 1.3 |
5.3 ± 0.8 |
| SOD1 |
16.1 ± 5.2 |
19.3 ± 5.1 |
33.6 ± 11.0 |
69.6 ± 15.6abc |
| SOD2 |
7.9 ± 2.1 |
6.6 ± 1.5 |
6.7 ± 2.6 |
19.5 ± 4.0abc |
| SOD3 |
1.7 ± 0.4 |
1.51 ± 0.2 |
2.5 ± 1.3 |
2.9 ± 0.8 |
| Gpx |
16.5 ± 4.3 |
42.2 ± 10.2 |
56.4 ± 22.7 |
40.5 ± 6.0a |
| Catalase | 19.4 ± 5.1 | 28.1 ± 8.1 | 34.4 ± 10.3 | 52.0 ± 9.0 |
The values represent the mean ± SEM, with all results normalised to 18 s ribosomal mRNA. Statistically significant differences (P < 0.05) between groups are indicated by lower case letters, where a6 m/o, b12 m/o, c18 m/o and d24 m/o.