X-ray crystal structures of (a) wild-type MR (2R14.pdb) (11) and (b) wild-type PETNR (3KFT.pdb) (9) bound to nonreactive NADH analog; (c) an overlay of the key residues (MR: cyan, orange, purple, PETNR: yellow) in the coenzyme binding site and nicotinamide ring of the coenzyme (MR: dark blue, PETNR: light blue), aligned on the isoalloxazine ring of the FMN (MR: dark red, PETNR: light red); and (d) catalytic cycle of MR and PETNR, adapted from (12). To see this figure in color, go online.