Table 2.
Laboratory data of the SLE patients and control subjects
|
SLE patients (n = 23) |
SJS patients (n = 9) |
Healthy controls (n = 20) |
pvalue | |
|---|---|---|---|---|
| White blood cells (×103/ml) |
6.73 ± 2.5 |
6.47 ± 1.97 |
5.68 ± 1.89 |
0.442 |
| % granulocyte |
69.49 ± 13.19 |
65.93 ± 10.22 |
61.6 ± 12.76 |
0.341 |
| % lymphocyte |
22.81 ± 11.65 |
25.33 ± 9.15 |
31.01 ± 10.85 |
0.232 |
| % monocyte |
5.57 ± 3.00 |
6.19 ± 2.44 |
5.63 ± 1.74 |
0.873 |
| Hemoglobulin (mg/dL) |
11.73 ± 1.73 |
12.38 ± 0.99 |
14.06 ± 1.86 |
0.003α |
| Platelet counts (×104/ml) |
22.13 ± 8.49 |
23.67 ± 5.39 |
22.26 ± 6.19 |
0.851 |
| Autoantibodies titers |
|
|
|
|
| a-dsdna |
18 (1.7, 70.0) |
ND |
ND |
ND |
| a-ro |
0.5 (0.1, 240) |
84.75 (0.3, 217.5) |
ND |
0.725 |
| a-ro52 |
0.3 (0.1, 32) |
ND |
ND |
ND |
| a-ro60 |
0.9 (0, 300) |
ND |
ND |
ND |
| a-la |
0.2 (0, 3.3) |
0.2 (0.1, 4.45) |
ND |
0.896 |
| a-mi2 |
0.1 (0, 0.2) |
ND |
ND |
ND |
| Apoptosis tested by flow cytometry? |
|
|
|
|
| Leukocyte apoptosis (%) |
|
|
|
|
| Annexin V (%) |
15.3 (8.9-18.2) |
9.87 (8.29-12.50) |
10.9 (8.8-13.4) |
0.005β |
| APO2.7 (%) |
1.3 (0.9-2.2) |
1.10(0.70-1.57) |
0.7 (0.5-0.9) |
0.001γ |
| Annexin V + 7AAD (%) |
7.1 (3.8-11.8) |
6.58(2.80-10.10) |
3.2 (2.6-4.5) |
0.011δ |
| Neutrophil apoptosis (%) |
|
|
|
|
| Annexin V (%) |
21.6 (11.7-28.8) |
9.15 (7.80-15.76) |
13.9 (10.3-18.0) |
0.010ϵ |
| APO2.7 (%) |
0.6 (0.4-1.3) |
0.79(0.40-1.05) |
0.5 (0.4-0.6) |
0.001ζ |
| Annexin V + 7AAD (%) |
10.7 (3.1-22.8) |
6.93(1.97-20.60) |
3.9 (2.2-5.5) |
0.026η |
| Lymphocyte apoptosis (%) |
|
|
|
|
| Annexin V (%) |
8.4 (4.9-12.1) |
6.10 (5.11-8.23) |
4.8 (3.8-6.7) |
0.009θ |
| APO2.7 (%) |
0.7 (0.5-1.0) |
0.46(0.43-0.78) |
0.3 (0.2-0.4) |
0.008κ |
| Annexin V + 7AAD (%) |
2.1 (1.2-3.6) |
1.46(0.67-2.92) |
1.5 (0.9-2.1) |
0.101 |
| Monocyte apoptosis (%) |
|
|
|
|
| Annexin V (%) |
19.6 (13.5-27.3) |
13.83 (11.42-15.38) |
17.4 (12.4-21.6) |
0.032λ |
| APO2.7 (%) |
3.0 (2.5-6.8) |
1.94 (1.48-3.27) |
1.8 (1.1-2.7) |
0.088 |
| Annexin V + 7AAD (%) | 10.4 (5.3-17.8) | 7.63 (3.34-15.36) | 4.6 (3.3-6.0) | 0.024μ |
Abbreviations: SLE Systemic lupus erythematosus, SJS Sjogren’s syndrome, WBC White blood cells or leukocytes, 7-AAD 7-amino-actinomycin D, SD Standard deviation, IQR Inter-quartile range, A-dsdna Anti-dsDNA, A-ro Anti-Ro52/60, A-ro52 Anti-Ro 52 kDa, A-ro60 Anti-Ro 60 kDa, A-la Anti-La, ND Not done.
ϮFigures are median (IQR) or number (%).
Results of Bonferroni multiple comparisons for post hoc test (SLE vs. control, SLE vs. SJS, or SJS vs. control).
α, SLE vs. control = 0.002; β, SLE vs. control = 0.014, SLE vs. SJS = 0.029; γ, SLE vs. control = 0.001; δ, SLE vs. control = 0.009; ϵ, SLE vs. control = 0.005, SLE vs. SJS = 0.004; ζ, SLE vs. control = 0.041; η, SLE vs. control = 0.021; θ, SLE vs. control = 0.008; κ, SLE vs. control = 0.007; λ, SLE vs. SJS = 0.036; μ, SLE vs. control = 0.026.