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Correlation between individual phenobarbital doses and maximal plasma concentrations. As a result of the different body weights of the 8 dogs, doses of phenobarbital ranged between 5.8 and 11.1 mg/kg, resulting in different peak plasma levels (Cmax). As shown in the graph, a linear correlation between Cmax and dose was obtained for both phenobarbital formulations without difference between formulations.
