Table 1.
Pharmacokinetic parameters of phenobarbital following oral administration of 100 mg Luminal® vet or Phenoleptil® in a group of 8 dogs
| Parameter | Luminal® vet | Phenoleptil® | P |
|---|---|---|---|
| Tmax (h) observed |
3.75 ± 0.79 |
2.75 ± 0.37 |
0.2275 |
| Tmax (h) calculated |
5.97 ± 1.33 |
2.64 ± 0.51 |
0.0588 |
| Cmax (μg/ml) observed |
10.9 ± 0.92 |
10.5 ± 0.77 |
0.2426 |
| Cmax (μg/ml) calculated |
10.3 ± 0.92 |
10.0 ± 0.85 |
0.2569 |
| T0.5 (h) |
50.3 ± 3.1 |
52.9 ± 2.8 |
0.2348 |
| AUC(0-119) (μg ml-1 h) observed |
644 ± 52.5 |
618 ± 44.5 |
0.1499 |
| AUC∞ (μg ml-1 h) calculated |
807 ± 66.8 |
781 ± 54.0 |
0.2961 |
| Relative bioavailability (AUCPhenoleptil® /AUCLuminal® vet) |
0.98 ± 0.031 |
||
| (range: 0.90-1.15; 90% CI: 0.92-1.04) | |||
| Relative Cmax observed (Cmax, observed Phenoleptil®/ Cmax, observed Luminal® vet) |
0.96 ± 0.031 |
||
| (range: 0.85-1.05; 90% CI: 0.90-1.03) | |||
| Relative Cmax calculated (Cmax, calculated, Phenoleptil®)/Cmax, calculated, Luminal® vet) |
0.97 ± 0.028 |
||
| (range: 0.81-1.08; 90% CI: 0.92-1.03) | |||
All data are shown as means ± SEM; for ratios also the range and 90% confidence intervals (90% CI) are shown. Abbreviations: Tmax, time to reach peak plasma concentration; Cmax, peak plasma concentration; t0.5, elimination half-life in plasma; AUC, area under the plasma concentration curve.