Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct 17;14(1):108. doi: 10.1186/1465-9921-14-108

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 Winden et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Lung histology and ultrastructure in RAGE TG mice compared to controls. Significant lung hypoplasia was observed in RAGE TG mice exposed to doxycycline from conception to E18.5 (B) compared to lungs from control littermates (A). Images were at 100X original magnification. Electron microscopy of RAGE TG and control mice fed doxycycline from conception until sacrifice date at E18.5 revealed altered basement membrane (BM) integrity in the alveolar compartment. Wild type BM was distinct and pronounced (C, arrow) compared to RAGE TG BM that appeared diminished and fragmented (D, arrow). Magnification for each image is 6,500X.