Table 3.
Cox regression analyses of clinicopathological factors, RECK and EMMPRIN in 181 cases* of pN0/M0 renal carcinoma
|
Variable |
Univariate analyses |
Multivariate analyses (RECK) |
Multivariate analyses (EMMPRIN) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
Inclusion |
|
Backward** |
|
Inclusion |
|
Backward** |
|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Sex |
0.764 |
0.361 |
0.766 |
0.405 |
|
|
0.745 |
0.356 |
|
|
| Male / female |
(0.429-1.362) |
|
(0.409-1.434) |
|
|
|
(0.398-1.393) |
|
|
|
| Age |
1.047 |
0.006 |
1.047 |
0.008 |
1.048 |
0.006 |
1.049 |
0.006 |
1.046 |
0.009 |
| continous |
(1.013-1.081) |
|
(1.012-1.083) |
|
(1.013-1.083) |
|
(1.014-1.086) |
|
(1.011-1.082) |
|
| pT stage |
2.800 |
<0.001 |
2.595 |
0.001 |
2.958 |
<0.001 |
2.521 |
0.002 |
2.581 |
0.002 |
| pT1-2 / pT3-4 |
(1.628-4.817) |
|
(1.443-4.669) |
|
(1.690-5.175) |
|
(1.397-4.548) |
|
(1.434-4.643) |
|
| Fuhrman grade |
1.569 |
0.242 |
1.467 |
0.365 |
|
|
1.130 |
0.779 |
|
|
| G1-2 / G3-4 |
(0.738-3.333) |
|
(0.640-3.363) |
|
|
|
(0.481-2.656) |
|
|
|
| Surgical margin status*** |
5.818 |
0.001 |
2.342 |
0.143 |
|
|
2.825 |
0.078 |
2.879 |
0.068 |
| R negative / positive |
(2.006-16.879) |
|
(0.750-7.308) |
|
|
|
(0.891-8.953) |
|
(0.926-8.950) |
|
| RECK expression |
1.063 |
0.880 |
1.040 |
0.930 |
|
|
|
|
|
|
| negative / positive |
(0.479-2.358) |
|
(0.431-2.510) |
|
|
|
|
|
|
|
| EMMPRIN expression* |
2.815 |
0.005 |
|
|
|
|
2.538 |
0.014 |
2.546 |
0.012 |
| low (0,1) / high (2/3) | (1.372-5.776) | (1.208-5.333) | (1.229-5.277) | |||||||
*EMMPRIN expression in 180 cases: 153 clear cell, 17 papillary (18 for RECK), 10 chromophobe renal cell carcinomas. Oncocytomas were excluded due to benignity. **Reduced model following backward Likelihood elimination (P = 0.05 for entry and P = 0.10 for removal). ***175 cases, 6 cases were Rx. Abbreviations: HR Hazard ratio, CI Confidence interval, PP value.