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. 2013 Oct 22;14(Suppl 16):S4. doi: 10.1186/1471-2105-14-S16-S4

Figure 7.

Figure 7

Evaluation of phenotypic profiling. (a) Multidimensional scaling plot based on the cosine dissimilarities among the d-profiles for the 32 siRNAs, which are color-coded according to their known biological functions. (b) Mean intra- and inter-group dissimilarities of phenotypic profiles constructed for 32 siRNAs in the HeLa dataset based on mean-, principal-component-analysis-(PCA)-based, and "d-profiles" (error bars = SEM, * = P<0.05, ** = P<0.01, *** = <0.001; two-sided paired t-test.). (c) Inter-group dissimilarities of mean-, PCA-based and d-profiles for different numbers of nearest neighbors. (Error bars = SEM).