Table 3.

PK model development process

Step	Model testeda	Objective function value
1	One-compartment model with first-order absorption	2138.416
	One-compartment model with first-order absorption (with lag-time)	2130.609
2	Two-compartment model with first-order absorption	2037.527
	Two-compartment model with first-order absorption (with lag-time)	1993.071
	Two-compartment model with saturable absorption (Michaelis Menten absorption)	2140.583
3	Two-compartment model with zero-order absorption	1885.795
4	One-compartment model with a mixture of zero and first-order absorption	1879.067
	One-compartment model with Michaelis Menten elimination and a mixture of zero- and first-order absorption	2163.942

^aThe elimination process was assumed to follow first-order kinetics.