TABLE 2.

Pharmacologic parameters of signaling by chemokine receptors

Concentration-response data were fit with simple logistic equations with Hill coefficients equal to 1, allowing determination of maximal response (E_max) and EC₅₀ for G protein signaling, βarr recruitment, and receptor internalization. Bias factors (β) were calculated as described under “Experimental Procedures.” Bias factors that were statistically significantly different from the arbitrarily defined balanced agonist with a bias factor of 0 (p < 0.05 by unpaired t test) are in bold. Data from at least three experiments were used for the fits. S.E., standard error; N.D., not determined.