Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for the proposed glycan-independent (A) and glycan-dependent (B) modes of calreticulin-substrate interactions. Glycan-dependent binding is predicted to induce an open P-domain conformation (B, left panel), with subsequent ERp57 binding inducing a closed conformation (B, right panel).
