TABLE 1.

Target selectivity of inhibitors against class I PI3Ks

Inhibitor	PI3K isoform (from low to high IC50)	Ref.
PIK75	p110α > p110γ > p110δ, p110β	22, 47
TGX221	p110β > p110δ ≫ p110α, p110γ	48
AS252424	p110 γ ≫ p110α, p110β, p110δ	24
GS-9820	p110δ ≫ p110γ, p110β, p110α	Table 2
IC87114	p110δ ≫ p110γ, p110β, p110α	25
GDC0491	p110α ≈ p110δ > p110β ≈ p110γ	48
Wortmannin	p110β ≈ p110α ≈ p110δ ≈ p110γ	48
LY294002	p110α ≈ p110δ ≈ p110β ≈ p110γ	48