TABLE 1.
Inhibitor | PI3K isoform (from low to high IC50) | Ref. |
---|---|---|
PIK75 | p110α > p110γ > p110δ, p110β | 22, 47 |
TGX221 | p110β > p110δ ≫ p110α, p110γ | 48 |
AS252424 | p110 γ ≫ p110α, p110β, p110δ | 24 |
GS-9820 | p110δ ≫ p110γ, p110β, p110α | Table 2 |
IC87114 | p110δ ≫ p110γ, p110β, p110α | 25 |
GDC0491 | p110α ≈ p110δ > p110β ≈ p110γ | 48 |
Wortmannin | p110β ≈ p110α ≈ p110δ ≈ p110γ | 48 |
LY294002 | p110α ≈ p110δ ≈ p110β ≈ p110γ | 48 |