Skip to main content
. 2013 Oct 22;288(49):35372–35386. doi: 10.1074/jbc.M113.507426

FIGURE 1.

FIGURE 1.

Fetal splicing programs are activated in diabetic hearts. A, qRT-PCR using RNA from mouse heart tissues. Percent inclusion of hnRNPH1 exon6, Mtmr3 exon16, Fxr1 exon15 + 16, Atp2b1 exon21, and Mbnl2 exon8 in hearts from normal C57BL/6 newborn mice (gray bars) and saline (white bars) or STZ-treated C57BL/6 adult mice (black bars) (n ≥ 3). B, percent inclusion of hnRNPH1 exon6 and Mtmr3 exon16 in hearts from wild type newborn FVB mice and in NOD adult mice with low glucose (control) or high glucose (T1D/NOD). Hearts from newborn mice were pooled (n ≥ 3). C, percent inclusion of hnRNPH1 exon6, Mtmr3 exon16, and Fxr1 exon15 + 16 in nondiabetic (control) or type 2 diabetic human (T2D/human) hearts (n = 3). Unpaired t test was used to calculate statistically significant difference between two samples (n ≥ 3).