TABLE 1.
Reported ERM-interacting proteins
| Interaction partner | Selected refs. | Proposed binding mode | Proposed function |
|---|---|---|---|
| Aquaporin-0 | 50 | Unknown | Unknown |
| ARHGAP-18/conundrum | 33 | FERM domain | Active RhoA level |
| Bitesize | 51 | FERM domain (lobe F3) | Adherens junction morphology |
| CD146 | 52 | Unknown | Melanoma cell line migration through control of ERM-RhoGDI interaction |
| CD43 | 20, 53–56 | FERM domain | Lymphocyte migration via PKC-mediated phosphorylation of CD43 tail; tethering of ERMs to plasma membrane for microvillus formation |
| CD44 | 9, 20, 53, 57–62 | FERM domain | Migration speed and directionality; lymphocyte polarization; microvilli length and number |
| CLIC3/4/5 | 32, 42 | C-terminal region of ezrin | Microvillus formation in RPE cells (CLIC4) |
| Dbl | 48, 63–67 | FERM domain with Dbl PH | Active Cdc42 level |
| DCC | 68, 69 | FERM domain | Netrin-induced axon guidance |
| Dlg1 | 70, 71 | FERM domain | Immune synapse formation |
| SLC9A3R1/2 (EBP50/E3KARP) | 17, 18, 21, 28, 30, 49, 72 | FERM domain | Microvilli formation; clustering of various receptors |
| Eps8/−L1a | 73 | Coiled-coil domain NPXY motif with Eps8 SH3 | Microvillus length and spacing |
| Fes | 74 | Coiled-coil domain NPXY motif with Fes SH3 | Cell spreading and migration in response to HGF |
| ICAM-1/-2/-3 | 24, 25, 75–79 | FERM domain | Polarization of ICAMs to the uropod in migrating lymphocytes; microvilli length and number |
| L1CAM | 80, 81 | FERM domain | Neurite outgrowth |
| Myo18aα | 82 | Unknown | Unknown |
| NHE-1 | 83, 84 | FERM domain | Migration speed and directionality |
| NHE-3 | 85 | FERM domain | NHE-3 surface distribution in OK cells |
| SCYL3/PACE-1 | 34 | C-terminal region of ezrin | Unknown |
| Palladin | 86, 87 | Ezrin (278–585) with palladin Ig2/3 | Unknown |
| PDZD8 | 88 | Unknown | Glutamylated microtubule abundance and HSV-1 viral entry |
| PLEKHG6 | 89 | FERM domain with PLEKHG6 C-terminal region | Macropinocytosis |
| Podocalyxin | 90 | Unknown | Unknown |
| PSGL-1 | 78, 91–95 | FERM domain | Lymphocyte rolling on P-selectin |
| Rab11 | 96 | Unknown | Collective cell migration |
| Ras | 97 | FERM domain | Active Ras level |
| RhoGDI | 9, 66, 98 | FERM domain | Active Rho GTPase level |
| S100P | 99, 100 | FERM domain | Cellular calcium response |
| SAP97 | 101 | Unknown | Unknown |
| SOS | 97 | FERM domain with SOS DH/PH | Active Ras level |
| SYND2/Syndecan-2 | 35, 36 | FERM domain | Unknown |
| Vps11/HOPS | 102 | Coiled-coil domain | Endocytosis |
| WWOX | 103 | Coiled-coil domain NPXY motif with WWOX SH3 | Secretion in gastric parietal cells |
| WWP-1 | 104 | Coiled-coil domain NPXY motif with WWP-1 SH3 | Cell migration in response to HGF |
| ZAP-70 | 55 | Unknown | Immune synapse formation |
| ITGB4/β4 integrin | 105 | FERM domain | β4 integrin protein level |
| DAG1/β-Dystroglycan | 41, 48 | FERM domain | Filopodia formation in C2C12 cells co-transfected with active Cdc42 |