Table 1.
Glucose, leptin, insulin, and C-peptide in serum.
| Group | Dose (mg/kg body weight/day) | Glucose (mg/dL) | Leptin (ng/dL) | Insulin (ng/mL) | C-peptide (pg/mL) |
|---|---|---|---|---|---|
| m/m | — | 186 ± 25c | 2.30 ± 0.32c | 1.82 ± 0.06b | 177 ± 15c |
| db/db | |||||
| Veh | — | 791 ± 42 | 20.24 ± 0.29 | 3.72 ± 0.45 | 1,983 ± 277 |
| GS | 20 | 745 ± 31 | 18.51 ± 0.75 | 2.68 ± 0.11a | 1,135 ± 139a |
| GS | 100 | 683 ± 41 | 17.57 ± 0.87a | 2.40 ± 0.04b | 970 ± 142b |
m/m, Misty; Veh, vehicle-treated db/db mice; GS20, GS20 mg/kg body weight-treated db/db mice; GS100, GS100 mg/kg body weight-treated db/db mice. The results are presented as the means ± S.E.M. a P < 0.05, b P < 0.01, c P < 0.001 versus vehicle-treated db/db mouse values.