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. Author manuscript; available in PMC: 2013 Dec 6.
Published in final edited form as: Annu Rev Immunol. 2013;31:10.1146/annurev-immunol-020711-074950. doi: 10.1146/annurev-immunol-020711-074950

Figure 5.

Figure 5

DC controllers of adaptive immunity. This illustration summarizes key DC functions, highlighting their importance as regulators of adaptive immune functions in lymphoid and nonlymphoid tissues. DC subsets that populate peripheral tissues capture commensals, food antigens, or exogenous antigens and migrate in a CCR7-dependent manner to the draining lymph node, where they present tissue-derived antigens to CD8+ T cells (cross-presentation) and CD4+ T cells (direct presentation), thereby inducing peripheral tolerance in the steady state or effector immunity in the injured state. Gut tissue CD103+ cDCs that migrate to the draining lymph node can promote the induction of gut-homing molecules (α4β7 and CCR9) on naive T cells (tissue imprinting), thereby promoting T cell migration to gut tissue. cDCs also promote T cell–dependent class switch recombination (CSR).