Table 2.

Medians and 25th-75th percentiles (P25-P75) of log10 mRNA of podocyte-associated proteins in urine by stage of diabetic nephropathy, in subjects with prediabetes and in controls

				Diabetes
Log 10 mRNA Urinary	Controls (n = 15)	Prediabetes (n = 19)	Normoalbuminuria (n = 34)	Microalbuminuria (n = 14)	Macroalbuminuria (n = 19)	p-value
Nephrin	2.03(1.49-2.67)	2.03(1.20-2.93)	2.85(2.14-3.63)	3.35(2.14-5.48)	4.21(3.16-4.95)	<0.001
Podocin	1.57(1.32-2.33)	2.22(1.83-3.25)	2.67(2.12-4.00)	2.54(1.72-3.99)	2.33(1.64-3.62)	0.150
Podocalyxin	1.68(1.18-2.53)	2.10(1.41-2.83)	3.04(2.35-3.76)	3.51(2.79-5.13)	2.89(2.69-3.42)	<0.001
Synaptopodin	1.72(1.30-2.60)	1.86(1.22-2.29)	2.93(1.88-3.12)	2.61(1.13-3.33)	1.62(1.02-4.30)	0.112
TRPC6	1.97(1.21-2.83)	1.69(0.97-2.53)	3.06(1.96-3.83)	2.40(1.89-4.17)	3.06(2.25-4.29)	0.001
Alpha actinin-4	1.94(1.24-3.11)	2.44(1.74-2.67)	3.26(2.48-4.23)	3.54(2.45-4.75)	2.70(2.38-4.08)	<0.001
TGFβ1	2.21(0.78-2.96)	2.59(1.98-3.30)	2.75(2.25-3.86)	2.31(1.40-4.18)	3.02(1.97-4.15)	0.241

Controls: C; Prediabetes: PD; Diabetes with normoalbuminuria: NO; Diabetes with microalbuminuria: MI; Diabetes with macroalbuminuria: MA.

Nephrin: MA vs. C and PD (P<0.001); MI vs. PD and MA vs. NO (P<0.05); MI vs. C, NO vs. C and PD (P<0.05).

Podocalyxin: MI vs. C (P<0.001); MA vs. C, NO vs. C, and MI vs. PD (P<0.05); NO vs. PD (P=0.035).

TRPC6: MA vs. PD and NO vs. PD (P<0.05); MA vs. C (P=0.049).

Alpha actinin-4: NO vs. PD and C (P<0.05); MI vs. PD (P=0.032).