Figure 4.

Morpholino Knockdown of Slc38a8 in Medaka Fish Results in Microphthalmia, Coloboma, and Lens Defects, but No Skin- or Ocular-Pigmentation Abnormalities

(A) Bright-field stereomicroscope images show lateral views of representative fish for the controls and Mo-5′UTR-slc38a8 c3+c6 and Mo-5′UTR-Slc38a8 c3+c6/Mo-p53 mutants. The red bracket highlights the reduced eye size in morphants, and the arrows highlight displaced lenses. Ocular pigmentation identical to that of the controls can clearly be seen in the mutant fish.

(B) The frequency of each phenotype observed in the medaka fish is given as a percentage of 300.