Table 2.
Major KEGG pathways altered in MPA treated AGS cells
| Pathway Name | Gene # | Gene # changed | pFDR-12 | Status-12 | pFDR-24 | Status-24 | pFDR-48 | Status-48 | pFDR-72 | Status-72 |
|---|---|---|---|---|---|---|---|---|---|---|
| p53 signaling pathway | 68 | 22 | 6E-11 | I | 7E-11 | I | 8E-11 | I | 9E-11 | I |
| Cell cycle | 123 | 22 | 5E-06 | I | 5E-06 | I | 4E-06 | I | 3E-06 | I |
| Pathways in cancer | 328 | 35 | 4E-04 | I | 3E-04 | A | 3E-04 | A | 3E-04 | I |
| Small cell lung cancer | 87 | 15 | 5E-04 | A | 2E-04 | A | 7E-05 | A | 1E-04 | A |
| PPAR signaling pathway | 71 | 10 | 2E-03 | I | 1E-03 | I | 1E-03 | I | 2E-03 | I |
| HTLV-I infection | 259 | 27 | 2E-03 | I | 2E-03 | I | 2E-03 | I | 2E-03 | I |
| Bladder cancer | 42 | 9 | 7E-03 | I | 7E-03 | A | 6E-03 | A | 7E-03 | A |
| Protein processing in ER | 163 | 18 | 1E-02 | I | 6E-03 | I | 8E-03 | I | 8E-03 | I |
| MAPK signaling pathway | 266 | 24 | 1E-02 | I | 3E-02 | I | 2E-02 | I | 2E-02 | I |
| Pathogenic E. coli infection | 54 | 9 | 2E-02 | I | 1E-02 | I | 1E-03 | I | 1E-03 | I |
I: inhibited; A: activated; pFDR: FDR p value for each time point (12, 24, 48 and 72 hours).