Table 4.
Selective genes differentially expressed after MPA treatment
| Genes | R12h | R24h | R48h | R72h | p-12h | p-24h | p-48h | p-72h |
|---|---|---|---|---|---|---|---|---|
| ABCA12 | 1.0 | 2.3 | 5.4 | 4.2 | 9.7E-01 | 3.7E-09 | 8.1E-15 | 2.6E-13 |
| ABCB9 | 2.3 | 3.4 | 4.3 | 2.9 | 6.2E-09 | 3.7E-12 | 1.4E-13 | 5.1E-11 |
| ATF3 | 5.6 | 6.3 | 7.0 | 6.8 | 3.8E-13 | 2.0E-14 | 6.5E-15 | 1.1E-14 |
| CDH10 | 1.5 | 3.1 | 4.8 | 7.4 | 2.6E-03 | 8.3E-10 | 2.8E-12 | 5.0E-14 |
| CEACAM1 | 2.8 | 6.0 | 5.3 | 2.9 | 1.9E-10 | 4.2E-15 | 1.3E-14 | 6.0E-11 |
| CITED2 | 2.2 | 2.2 | 4.6 | 3.5 | 1.5E-06 | 6.8E-07 | 1.9E-11 | 7.8E-10 |
| CYR61 | 2.7 | 3.5 | 4.9 | 3.5 | 8.1E-09 | 5.3E-11 | 8.3E-13 | 7.6E-11 |
| GRIN2C | 5.9 | 8.3 | 9.6 | 10.6 | 6.4E-14 | 4.3E-16 | 1.3E-16 | 5.8E-17 |
| NOS3 | 1.1 | 1.6 | 4.7 | 6.5 | 8.3E-01 | 4.3E-05 | 4.8E-14 | 1.9E-15 |
| NPPB | 2.9 | 8.9 | 17.0 | 11.6 | 1.4E-07 | 4.0E-13 | 3.1E-15 | 6.5E-14 |
| RN7SK | 3.6 | 12.1 | 81.6 | 176.9 | 3.7E-11 | 1.2E-16 | 6.2E-22 | 1.5E-23 |
| RNA28S5 | 1.0 | 1.2 | 15.9 | 40.4 | 9.2E-01 | 3.6E-01 | 3.1E-15 | 2.9E-17 |
| SLC30A1 | 5.3 | 6.3 | 3.8 | 3.4 | 7.6E-13 | 2.1E-14 | 6.3E-12 | 4.4E-11 |
| SLC30A1 | 4.6 | 5.5 | 3.9 | 4.0 | 2.4E-13 | 6.5E-15 | 3.5E-13 | 3.7E-13 |
| SLC31A2 | 2.8 | 4.1 | 2.9 | 3.4 | 4.9E-11 | 4.4E-14 | 7.3E-12 | 1.0E-12 |
| SMAD3 | 1.6 | 4.3 | 3.6 | 2.7 | 1.5E-04 | 1.2E-12 | 1.5E-11 | 1.0E-09 |
| TP53I3 | 5.4 | 12.0 | 11.0 | 7.7 | 1.2E-13 | 4.2E-17 | 5.7E-17 | 8.6E-16 |
| TP53INP1 | 3.2 | 4.2 | 4.3 | 4.0 | 7.1E-11 | 6.0E-13 | 4.5E-13 | 1.8E-12 |
| TXNIP | 2.7 | 3.1 | 5.5 | 6.1 | 2.5E-09 | 9.3E-11 | 7.5E-14 | 3.1E-14 |
| ARRB1 | 0.18 | 0.20 | 0.19 | 0.18 | 3.0E-14 | 8.1E-15 | 5.1E-15 | 2.8E-15 |
| CHN2 | 0.38 | 0.37 | 0.27 | 0.32 | 2.4E-09 | 4.1E-10 | 3.5E-12 | 6.0E-11 |
| CLDN2 | 0.53 | 0.37 | 0.23 | 0.22 | 5.9E-07 | 2.2E-10 | 2.0E-13 | 1.7E-13 |
| D2HGDH | 0.71 | 0.29 | 0.20 | 0.23 | 1.2E-03 | 3.6E-12 | 2.3E-14 | 2.0E-13 |
| ESRRG | 0.29 | 0.28 | 0.26 | 0.29 | 1.5E-08 | 4.7E-09 | 2.7E-09 | 1.3E-08 |
| HSPA5 | 0.22 | 0.18 | 0.25 | 0.28 | 1.8E-12 | 2.8E-14 | 1.4E-12 | 8.2E-12 |
| IGFBP5 | 0.14 | 0.10 | 0.10 | 0.09 | 1.2E-13 | 9.6E-16 | 1.0E-15 | 8.6E-16 |
| INF2 | 0.25 | 0.22 | 0.24 | 0.24 | 4.9E-11 | 4.4E-12 | 1.1E-11 | 1.7E-11 |
| LRP8 | 0.43 | 0.31 | 0.20 | 0.27 | 1.9E-08 | 4.6E-11 | 2.0E-13 | 7.2E-12 |
| NAV2 | 0.18 | 0.17 | 0.13 | 0.12 | 1.3E-12 | 1.7E-13 | 1.0E-14 | 6.6E-15 |
| PAGE4 | 0.63 | 0.34 | 0.14 | 0.10 | 2.9E-04 | 9.0E-10 | 2.3E-14 | 1.9E-15 |
| PDGFRA | 0.41 | 0.28 | 0.23 | 0.16 | 7.3E-09 | 5.1E-12 | 4.7E-13 | 1.1E-14 |
| PLA2G2A | 0.68 | 0.41 | 0.29 | 0.29 | 3.6E-03 | 5.6E-08 | 2.3E-10 | 4.4E-10 |
| PPARG | 0.56 | 0.33 | 0.28 | 0.35 | 2.2E-06 | 4.2E-11 | 2.3E-12 | 1.3E-10 |
| PRKCA | 0.31 | 0.35 | 0.28 | 0.27 | 3.7E-11 | 8.4E-11 | 2.8E-12 | 3.5E-12 |
| SNCAIP | 0.31 | 0.18 | 0.12 | 0.14 | 1.7E-10 | 7.3E-14 | 1.3E-15 | 5.4E-15 |
| AURKA | 0.73 | 0.68 | 0.64 | 0.54 | 1.3E-03 | 1.2E-04 | 1.6E-05 | 1.4E-07 |
| AURKB | 0.96 | 0.82 | 0.50 | 0.51 | 9.1E-01 | 1.8E-01 | 3.3E-06 | 5.0E-06 |
| FOXM1 | 0.79 | 0.65 | 0.42 | 0.54 | 1.3E-01 | 1.6E-03 | 1.5E-07 | 2.1E-05 |
| BOP1 | 0.48 | 0.34 | 0.41 | 0.57 | 3.4E-07 | 3.9E-10 | 8.6E-09 | 9.8E-06 |
| BUB1 | 0.66 | 0.52 | 0.39 | 0.42 | 1.8E-04 | 2.7E-07 | 6.4E-10 | 2.7E-09 |
| BUB1B | 0.61 | 0.66 | 0.62 | 0.56 | 3.0E-05 | 1.9E-04 | 2.8E-05 | 2.5E-06 |
| SRC | 0.97 | 0.82 | 0.67 | 0.56 | 9.2E-01 | 1.4E-01 | 9.0E-04 | 1.1E-05 |
R12h, R24h, R48h and R72h denote gene expression ratios at the respective time point over untreated control (0h). p-12h, p-24h, p48h and p72h denote p-values for the comparison between untreated control (0h) and the respective time point.