Figure 1.

A: The change of blood perfusion in the ischemic hindlimb was documented by serial laser Doppler imaging. A steep decrease in blood flow was observed soon after surgical ligation of the femoral artery followed by a gradual recovery. Treatment: mice were injected with pravastatin daily. Control: mice were injected with 0.9% sodium chloride solution daily. B: Quantitative data based on laser Doppler imaging. Blood flow in the ischemic hindlimb is expressed as percentage of the blood flow in the control hindlimb (n = 3). Blood flow recovered to near-normal levels faster in pravastatin treated mice than in the control group. *: P < 0.05.