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. 2013 Dec 1;6(1):102–103.

Figure 4.

Figure 4

BR-DIM regulated the expression of miR-34a, and the activity of AR pathway through demathylation. A: The miR-34a expression was up-regulated in cells treated with 5 μM of 5-aza-dC for 5 day compared with control cells (left panel) consistent with decreased expression of AR and PSA (right panel). B: The miR-34a expression was up-regulated in the cells treated with 6 μM of BR-DIM for 5 day compared with control cells (left panel) consistent with decreased expression of AR and PSA (right panel). C: C4-2B and LNCaP cells were treated with 5 μM 5-aza-dC or 6 μM BR-DIM for 5 days showing decreased methylation of miR-34a promoter. (C: control, aza-dC: 5-Aza-2'-deoxycytidine, BD: BR-DIM, *p<0.05, **p<0.01).