Table 4.
Top-ten consistently perturbed gene sets
| Gene set | Genes |
|---|---|
|
Up-regulated | |
| Adaptive immune response (MsigDB) |
MALT1 |
| Dissolution of fibrin clot (NCI) |
SERPINE1, PLAUR |
| Granulocytes pathway (BIOCARTA) |
ICAM1, IL8, IL1A |
| Inactivation of MAPK activity (MsigDB) |
DUSP8, DUSP6, SPRED2 |
| Viral genome replication (MsigDB) |
TNIP1, CCL2, IL8 |
| Hedgehog pathway up (NETPATH) |
PMP22, THBD, MYC |
| Positive regulation of immune response (MsigDB) |
FYN, EREG, MALT1 |
| CD28 dependent PI3K AKT signaling (REACTOME) |
MAP3K14, FYN, TRIB3, MAP3K8 |
| Peptidyl tyrosine phosphorylation (MsigDB) |
CLCF1, STAT1, IL12A, LYN |
| CDMAC pathway (BIOCARTA) |
NFKB1, NFKBIA, FOS, MYC, RELA |
|
Down-regulated | |
| LSM1-7 complex (CORUM) |
LSM4, LSM6, LSM2, LSM7 |
| Respiratory chain complex I incomplete intermediate mitochondrial (CORUM) |
NDUFS6, NDUFV2, NDUFS4, NDUFS7 |
| Mitochondrial respiratory chain (MsigDB) | UQCRC1, NDUFAB1, BCS1L, NDUFS4, NDUFS7, NDUFS3, NDUFS8, SURF1 |
Top-ten consistently perturbed gene sets, ranked by the number of genes they contain for up- and down- regulated gene sets.