Table 2.
Properties of sensory receptor subtypes in control, asic2−/− and asic2−/−:stomatin−/− mutant mice
| Mechanical search | Controls | asic2−/− | asic2−/−:stomatin−/− | ||
|---|---|---|---|---|---|
| Aβ-fibres | RAM | Percentage of total | 36% (15/42) | 42% (36/86) | 42% (39/92) |
| CV (m s−1) | 16.9 ± 1.3 | 18.8 ± 0.9 | 16.7 ± 0.6 | ||
| vFT (mN) | 1.0 (0.4–1.4) | 1.2 (1.0–3.3) | 0.4 (0.4–1.0) | ||
| SAM | Percentage of total | 64% (27/42) | 48% (50/86) | 58% (53/92) | |
| CV (m s−1) | 14.9 ± 1.0 | 18.8 ± 0.9 | 17.4 ± 0.6 | ||
| vFT (mN) | 3.3 (1.2–4.8) | 2.7 (1.1–6.3) | 1.0 (1.0–2.0) | ||
| Aδ-fibres | D-hair | Percentage of total | 41% (12/29) | 29% (18/62) | 54% (45/82) |
| CV (m s−1) | 6.1 ± 0.4 | 5.7 ± 0.4 | 5.4 ± 0.2 | ||
| vFT (mN) | 0.4 | 0.4 | 0.4 | ||
| AM | Percentage of total | 59% (17/29) | 71% (44/62) | 46% (38/82) | |
| CV (m s−1) | 4.8 ± 0.5 | 5.8 ± 0.3 | 4.9 ± 0.5 | ||
| vFT (mN) | 3.3 (2.0–6.3) | 3.3 (3.3–6.3) | 3.3 (3.3–10) | ||
| C-fibres | All C | Number | (32) | (15) | (40) |
| CV (m s−1) | 0.52 ± 0.03 | 0.45 ± 0.03 | 0.57 ± 0.03 | ||
| vFT (mN) | 6.3 (3.3–6.3) | 3.3 (2.0–5.5) | 3.3 (2–6.3) | ||
| CMH | Percentage of total | 40% (8/20) | 64% (7/11) | 63% (12/19) | |
| CV (m s−1) | 0.49 ± 0.02 | 0.40 ± 0.02 | 0.51 ± 0.04 | ||
| vFT (mN) | 2.0 (2.0–4.05) | 3.3 (2.65–4.8) | 3.3 (1.85–4.09) | ||
| CM | Percentage of total | 60% (12/20) | 36% (4/11) | 37% (7/19) | |
| CV (m s−1) | 0.52 ± 0.06 | 0.51 ± 0.06 | 0.61 ± 0.07 | ||
| vFT (mN) | 6.3 (3.3–10) | 2.7 (1.75–3.3) | 3.3 (2.65–4.8) | ||
| Electrical search | Controls | asic2−/− | asic2−/−:stomatin−/− | |
|---|---|---|---|---|
| Mechanically insensitive units | Aβ-fibres | 4% (1/24) | 12% (12/97) | 8% (2/24) |
| Aδ-fibres | 7% (4/57) | 5% (3/66) | 25% (12/48) | |
| C-fibres | 9% (3/32) | 7% (1/15) | 18% (7/37) | |
Properties of sensory receptor subtypes in control, asic2−/− and asic2−/−:stomatin−/− mice. Conduction velocity and von Frey mechanical threshold in mutant mice were compared to controls using the Mann–Whitney rank sum test. Proportions of mechanically insensitive receptors were compared using Fisher's exact test.*P < 0.05.