Table 2.

Repeated-dose study: mean (SD; n = 8) basal and pentagastrin-induced volume, H⁺ secretion rate and pH of gastric aspirate before and after placebo (Days 0 and 14) and before and after the first dose (Day 1) and last dose (Day 7) of 13 doses of netazepide (100 mg) twice daily

		Basal (0–30 min before dosing)	Pentagastrin (60–180 min after dosing)
	Day	Mean (SD)	Mean (SD)
Volume (ml min−1)	0	2.4 (1.7)	3.8 (1.3)
	1	1.3 (0.7)	0.8 (0.5)**
	7	1.0 (0.5)	1.3 (0.5)**
	14	1.6 (1.2)	3.2 (0.8)
H+ secretion rate (μmol min−1)	0	105 (73)	429 (250)
	1	59 (43)	30 (53)**
	7	41 (38)	51 (40)**
	14	108 (142)	405 (119)
pH	0	2.0 (1.3)	1.4 (0.5)
	1	1.9 (0.5)	4.3 (2.1)**
	7	2.2 (1.2)	1.9 (0.4)
	14	2.0 (1.0)	1.3 (0.4)

Asterisks show significant difference (**P < 0.001) from Day 0 by ANCOVA, with subject- and session-specific basal value as covariate.