Table 3.
Pharmacokinetic parameter estimates of melatonin
| Parameter estimates | 0.1 μg kg−1 h−1 | 0.02 μg kg−1 h−1 or 0.01 μg kg−1 h−1 |
|---|---|---|
| Observations | 23 | 23 |
| Number of patients | 8 | 8 |
| CL (l h−1/0.867 kg) | 0.045 (7.7%) | 0.012 (15.4%) |
| V (l/0.867 kg) | 1.098 (11.5%) | 0.364 (32.1%) |
| t1/2 (h) | 16.91 | 21.02 |
| Residual variability (CV%) | 30.24 (43.0%) | 62.93 (17.5%) |
Obtained from fitting the base model to two subsets of patients receiving the 0.1 μg kg−1 h−1 (over 2 h and 6 h) or the lower doses of melatonin infusion (0.02 μg kg−1 h−1 for 2 h, 0.01 μg kg−1 h−1 for 2 h). Pharmacokinetic parameter estimates are presented as mean (RSE%) and are scaled to a median weight of 0.867 kg. Variance terms are presented as CV% of the estimate (%RSE), where 
.