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Rituximab pharmacokinetic parameters
| Model | Value (95% confidence interval) | Coefficient of variation (%) |
|---|---|---|
| Clearance (CL; ml h−1) = θ1 × θ2PP | ||
| Clearance (CL; ml h−1) | θ1 = 6.64 (3.29–9.99) | 35.6 |
| Plasmapheresis factor (PP) | θ2 = 261 (146–376) | – |
| Central volume (V; l) | θ3 = 2.48 (1.78–3.18) | 20.5 |
| Transfer constant K12 (h−1) | θ4 = 0.0158 (0.0078–0.0238) | – |
| Transfer constant K21 (h−1) | θ5 = 0.0154 (0.0116–0.0192) | 40.1 |
| Interoccasion variability on CL | – | 14.7 |
| Interoccasion variability on V | – | 14.8 |
