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S-COMT activity (% of baseline, pre-dose day 1) vs. time curve following the first (day 1) and last (day 8) doses of a 8 day once daily regimen with opicapone (n = 6 per dose group of opicapone; n = 7 for placebo). 
, placebo; 
, 5 mg; 
, 10 mg; 
, 20 mg; 
, 30 mg
