Figure 5.

Proposed mechanism of COMT inhibition by nitrocatecholic compounds. E, I, EI and P are, respectively, COMT–AdoMet, inhibitor, COMT–AdoMet–inhibitor and O-methylated product. E* is the binary complex between COMT and AdoHcy and EI* is the non-productive ternary complex COMT–AdoHcy–inhibitor